PMID- 28343355
OWN - NLM
STAT- MEDLINE
DCOM- 20190306
LR  - 20190306
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 32
IP  - 9
DP  - 2017 Sep
TI  - Anti-C1q autoantibodies as markers of renal involvement in childhood-onset 
      systemic lupus erythematosus.
PG  - 1537-1545
LID - 10.1007/s00467-017-3646-z [doi]
AB  - BACKGROUND: Childhood-onset systemic lupus erythematosus (cSLE) is rare, and 
      considered more severe than its adult-onset counterpart. Lupus nephritis (LN) 
      occurs more frequently in children, accounting for higher long-term morbidity and 
      mortality compared with adults. Thus, reliable biological markers are needed to 
      predict disease course. This study aimed to investigate the capacity of anti-C1q 
      autoantibodies (Abs) to predict renal flare and global disease activity in cSLE 
      patients, and association with disease activity and kidney involvement. METHODS: 
      Twenty-eight patients with cSLE including 19 patients (68%) with a history of LN 
      were included retrospectively. Anti-C1q Abs were analysed by ELISA at renal 
      flare-up or in the quiescent phase of disease and compared with Farr dsDNA assay. 
      RESULTS: Thirty-one flares occurred during follow-up: anti-C1q Abs were positive 
      in 26 (84%), strongly associated with active disease status (p < 0.0001), and 
      correlated with global disease activity score (p < 0.0001) and anti-dsDNA Abs 
      presence (p < 0.0001). The specificity of anti-C1q Abs was higher than anti-dsDNA 
      (73% vs 19%) in discriminating LN patients, whereas the receiver operating 
      characteristic curves were not statistically different (0.83 +/- 0.06 vs 
      0.78 +/- 0.08 respectively), similar to C3 dosage. The presence of anti-C1q Abs at 
      diagnosis was not predictive for global or renal flare. Introduction of a 
      modified SLEDAI score excluding dsDNA Abs, demonstrated a stronger correlation of 
      anti-C1q Abs titres with SLEDAI score in comparison with the Farr test. 
      CONCLUSION: Anti-C1q Abs seem very specific to flares, including LN in children, 
      and their role in daily practice compared with the Farr dsDNA assay needs to be 
      defined.
FAU - Picard, Cecile
AU  - Picard C
AUID- ORCID: 0000-0001-9284-4531
AD  - Department of Pathology, Hopital Femme-Mere-Enfant, Hospices Civils de Lyon, 59 
      boulevard Pinel, 69500, Bron, France. cecile.picard@chu-lyon.fr.
AD  - Universite Claude Bernard Lyon 1, Lyon, France. cecile.picard@chu-lyon.fr.
FAU - Lega, Jean-Christophe
AU  - Lega JC
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, CNRS, Claude Bernard 
      University Lyon 1, University of Lyon, Lyon, France.
AD  - Department of Internal and Vascular Medicine, Centre Hospitalier Lyon-Sud, 
      Pierre-Benite, CHU de Lyon, Lyon, France.
FAU - Ranchin, Bruno
AU  - Ranchin B
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - Department of Pediatric Nephrology, Rheumatology and Dermatology, Hospices civils 
      de Lyon, Lyon, France.
FAU - Cochat, Pierre
AU  - Cochat P
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - Department of Pediatric Nephrology, Rheumatology and Dermatology, Hospices civils 
      de Lyon, Lyon, France.
FAU - Cabrera, Natalia
AU  - Cabrera N
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - Department of Pediatric Nephrology, Rheumatology and Dermatology, Hospices civils 
      de Lyon, Lyon, France.
FAU - Fabien, Nicole
AU  - Fabien N
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - Department of Immunology, Centre Hospitalier Lyon-Sud, Pierre-Benite, CHU de 
      Lyon, Lyon, France.
FAU - Belot, Alexandre
AU  - Belot A
AD  - Universite Claude Bernard Lyon 1, Lyon, France.
AD  - Department of Pediatric Nephrology, Rheumatology and Dermatology, Hospices civils 
      de Lyon, Lyon, France.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170325
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 80295-33-6 (Complement C1q)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Age of Onset
MH  - Autoantibodies/*blood/immunology
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - Complement C1q/*immunology
MH  - DNA/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Kidney/immunology
MH  - Lupus Nephritis/blood/*diagnosis/immunology
MH  - Male
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - *Symptom Flare Up
OTO - NOTNLM
OT  - Anti-C1q antibody
OT  - Biomarker
OT  - Childhood-onset systemic lupus erythematosus
OT  - Lupus nephritis
OT  - Pediatrics
OT  - SLEDAI
EDAT- 2017/03/28 06:00
MHDA- 2019/03/07 06:00
CRDT- 2017/03/27 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2017/03/07 00:00 [accepted]
PHST- 2017/03/05 00:00 [revised]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2019/03/07 06:00 [medline]
PHST- 2017/03/27 06:00 [entrez]
AID - 10.1007/s00467-017-3646-z [pii]
AID - 10.1007/s00467-017-3646-z [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2017 Sep;32(9):1537-1545. doi: 10.1007/s00467-017-3646-z. Epub 
      2017 Mar 25.