PMID- 28343871
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20220410
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 213
IP  - 5
DP  - 2017 May
TI  - Over-expression of CircRNA_100876 in non-small cell lung cancer and its 
      prognostic value.
PG  - 453-456
LID - S0344-0338(16)30522-2 [pii]
LID - 10.1016/j.prp.2017.02.011 [doi]
AB  - Circular RNAs (circRNAs) are a novel type of endogenous RNAs featuring stable 
      structure and high tissue-specific expression. Recently, accumulating evidence 
      has revealed that aberrant circRNAs expression plays important roles in 
      carcinogenesis and tumor progression. However, the expression pattern and 
      biological function of circRNAs in non small cell lung cancer (NSCLC) remain 
      largely unknown. Therefore, the purpose of this study was to clarify the possible 
      role of one of typical circRNAs, circRNA_100876 in NSCLC and to define its 
      prognostic value in NSCLC. Quantitative real-time polymerase chain reaction 
      (qRT-PCR) was used to detect the expression of circRNA_100876 in tumor tissues 
      and their adjacent nontumorous tissues in 101 patients with NSCLC. We found that 
      the expression level of circRNA_100876 was significantly elevated in NSCLC 
      tissues when compared with their adjacent nontumorous tissues (P=0.000). 
      Moreover, there was a close correlation between the circRNA_100876 up-regulation 
      expression and lymph node metastasis (P=0.001) and tumor staging (P=0.001) in 
      NSCLC. In addition, Kaplan-Meier survival analysis demonstrated that the overall 
      survival time of NSCLC patients with high circRNA_100876 expression was 
      significantly shorter than those patients with low circRNA_100876 expression 
      (P=0.000). In conclusion, our findings indicate that circRNA_100876 is closely 
      related to the carcinogenesis of NSCLC and it might be served as a potential 
      prognostic biomarker and therapeutic target for NSCLC.
CI  - Copyright (c) 2017 Elsevier GmbH. All rights reserved.
FAU - Yao, Jun-Tao
AU  - Yao JT
AD  - Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China; The Integrated Department of TCM and Western 
      Medicine, Affiliated Shaanxi Provincial Tumor Hospital of Medical College of 
      Xi'an Jiaotong University, Shaanxi Provincial Tumor Hospital, Xi'an 710061, 
      China.
FAU - Zhao, Shu-Hong
AU  - Zhao SH
AD  - Department of Radiation, Shaanxi Provinical People's Hospital, Xi'an 710068, 
      China.
FAU - Liu, Qiu-Ping
AU  - Liu QP
AD  - Third Ward of VIP, 323 Hospital of PLA, Xi'an 710054, China; Department of 
      Pathology, Medical School, Xi'an Jiaotong University, Xi'an 710061, China.
FAU - Lv, Mo-Qi
AU  - Lv MQ
AD  - Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an 710061, 
      China.
FAU - Zhou, Dang-Xia
AU  - Zhou DX
AD  - Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an 710061, 
      China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of 
      Education, Xi'an, 710061, China. Electronic address: zhoudx2010@163.com.
FAU - Liao, Zi-Jun
AU  - Liao ZJ
AD  - Department of First Internal Medicine, Affiliated Shaanxi Provincial Tumor 
      Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710061, China.
FAU - Nan, Ke-Jun
AU  - Nan KJ
AD  - Department of Oncology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an 710061, China.
LA  - eng
PT  - Journal Article
DEP - 20170222
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Circular)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Non-Small-Cell Lung/*diagnosis/genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*diagnosis/genetics/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA/*genetics
MH  - RNA, Circular
MH  - Up-Regulation
OTO - NOTNLM
OT  - Biomarker
OT  - CircRNA_100876
OT  - Non-small-cell lung cancer (NSCLC)
OT  - Prognosis
EDAT- 2017/03/28 06:00
MHDA- 2018/04/21 06:00
CRDT- 2017/03/28 06:00
PHST- 2016/10/10 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/02/17 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PHST- 2017/03/28 06:00 [entrez]
AID - S0344-0338(16)30522-2 [pii]
AID - 10.1016/j.prp.2017.02.011 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2017 May;213(5):453-456. doi: 10.1016/j.prp.2017.02.011. Epub 
      2017 Feb 22.