PMID- 28344659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 9
DP  - 2017
TI  - Comparison of in-hospital glycemic variability and admission blood glucose in 
      predicting short-term outcomes in non-diabetes patients with ST elevation 
      myocardial infarction underwent percutaneous coronary intervention.
PG  - 20
LID - 10.1186/s13098-017-0217-1 [doi]
LID - 20
AB  - AIMS: Admission hyperglycemia is associated with increased mortality and major 
      adverse cardiac events (MACE) in patients with or without diabetes mellitus after 
      acute myocardial infarction (AMI). However, effects of glycemic variability (GV) 
      on outcomes of non-diabetes patients with AMI still remains unclear. The aim of 
      this study is to compare the prognostic value of in-hospital GV with admission 
      blood glucose (ABG) for 3-month MACE in non-diabetes patients with ST elevation 
      myocardial infarction (STEMI) who underwent percutaneous coronary intervention 
      (PCI). METHODS: We analyzed 256 non-diabetes patients with STEMI in study. The GV 
      accessed by mean amplitude of glycemic excursions (MAGE) was calculated from 
      blood glucose profiles of continuous glucose monitoring system (CGMS) during 
      hospitalization. ABG was measured on admission. Main endpoints were 3-month MACE; 
      secondary endpoints were GRACE scores and enzymatic infarct size. Predictive 
      effects of MAGE and ABG on the MACE in patients were analyzed. RESULTS: In all 
      participants, MAGE level was associated with ABG level (r = 0.242, p < 0.001). 
      Both elevated MAGE levels (p = 0.001) and elevated ABG (p = 0.046) were 
      associated with incidences of short-term MACE. Patients with a higher MAGE level 
      had a significantly higher cardiac mortality (5.8 vs. 0.6%, p = 0.017) and 
      incidence of acute heart failure (12.8 vs. 2.4%, p = 0.001) during 3 months 
      follow-up. In multivariable analysis, high MAGE level (HR 2.165, p = 0.023) was 
      significantly associated with incidence of short-term MACE, but ABG (HR 1.632, 
      p = 0.184) was not. The area under the receiver-operating characteristic curve 
      for MAGE (0.690, p < 0.001) was superior to that for ABG (0.581, p = 0.076). 
      CONCLUSIONS: To compare with ABG, in-hospital GV may be a more important 
      predictor of short-term MACE and mortality in non-diabetes patients with STEMI 
      treated with PCI.
FAU - Mi, Shu-Hua
AU  - Mi SH
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Su, Gong
AU  - Su G
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Yang, Hong-Xia
AU  - Yang HX
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Zhou, Yun
AU  - Zhou Y
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Tian, Lei
AU  - Tian L
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Zhang, Tao
AU  - Zhang T
AD  - Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 
      Anzhen Road, Chaoyang District, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: 
      grid.24696.3f
FAU - Tao, Hong
AU  - Tao H
AD  - Department of Endocrinology, Beijing An Zhen Hospital, Capital Medical 
      University, Beijing, China. ISNI: 0000 0004 0369 153X. GRID: grid.24696.3f
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC5359987
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Admission blood glucose
OT  - Glycemic variability
OT  - Major adverse cardiac events
EDAT- 2017/03/28 06:00
MHDA- 2017/03/28 06:01
PMCR- 2017/03/21
CRDT- 2017/03/28 06:00
PHST- 2016/07/29 00:00 [received]
PHST- 2017/03/11 00:00 [accepted]
PHST- 2017/03/28 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/03/28 06:01 [medline]
PHST- 2017/03/21 00:00 [pmc-release]
AID - 217 [pii]
AID - 10.1186/s13098-017-0217-1 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2017 Mar 21;9:20. doi: 10.1186/s13098-017-0217-1. 
      eCollection 2017.