PMID- 28344668
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1759-720X (Print)
IS  - 1759-7218 (Electronic)
IS  - 1759-720X (Linking)
VI  - 9
IP  - 3
DP  - 2017 Mar
TI  - Diabetes and bone health: latest evidence and clinical implications.
PG  - 67-74
LID - 10.1177/1759720X16687480 [doi]
AB  - As the prevalence of diabetes is increasing worldwide, research on some of the 
      lesser-known effects, including impaired bone health, are gaining a lot of 
      attention. The two most common forms of diabetes are type 1 diabetes mellitus 
      (T1DM) and type 2 diabetes mellitus (T2DM). These two differ in their physiology, 
      with T1DM stemming from an inability to produce insulin, and T2DM involving an 
      insufficient response to the insulin that is produced. This review aims to 
      highlight the most current information regarding diabetes as it relates to bone 
      health. It looks at biochemical changes that characterize diabetic bone; notably 
      increased adiposity, altered bone metabolism, and variations in bone mineral 
      density (BMD). Then several hypotheses are analyzed, concerning how these changes 
      may be detrimental to the highly orchestrated processes that are involved in bone 
      formation and turnover, and ultimately result in the distinguishing features of 
      diabetic bone. The review proceeds by explaining the effects of antidiabetes 
      medications on bone health, then highlighting several ways that diabetes can play 
      a part in other clinical treatment outcomes. With diabetes negatively affecting 
      bone health and creating other clinical problems, and its treatment options 
      potentiating these effects, physicians should consider the use of 
      anti-osteoporotic drugs to supplement standard anti-diabetes medications in 
      patients suffering with diabetic bone loss.
FAU - Sundararaghavan, Vikram
AU  - Sundararaghavan V
AD  - Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, 
      OH, USA.
FAU - Mazur, Matthew M
AU  - Mazur MM
AD  - Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, 
      OH, USA.
FAU - Evans, Brad
AU  - Evans B
AD  - Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, 
      OH, USA.
FAU - Liu, Jiayong
AU  - Liu J
AD  - Department of Orthopaedic Surgery, University of Toledo Medical Center, 3065 
      Arlington Avenue, Toledo, OH 43614, USA.
FAU - Ebraheim, Nabil A
AU  - Ebraheim NA
AD  - Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, 
      OH, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170124
PL  - England
TA  - Ther Adv Musculoskelet Dis
JT  - Therapeutic advances in musculoskeletal disease
JID - 101517322
PMC - PMC5349336
OTO - NOTNLM
OT  - bone health
OT  - bone loss
OT  - bone turnover
OT  - diabetes
OT  - metabolism
OT  - type 1
OT  - type 2
COIS- Conflict of interest statement: The authors declare that there is no conflict of 
      interest.
EDAT- 2017/03/28 06:00
MHDA- 2017/03/28 06:01
PMCR- 2017/03/01
CRDT- 2017/03/28 06:00
PHST- 2017/03/28 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/03/28 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - 10.1177_1759720X16687480 [pii]
AID - 10.1177/1759720X16687480 [doi]
PST - ppublish
SO  - Ther Adv Musculoskelet Dis. 2017 Mar;9(3):67-74. doi: 10.1177/1759720X16687480. 
      Epub 2017 Jan 24.