PMID- 28344919
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2196-3029 (Print)
IS  - 2196-3029 (Electronic)
VI  - 2
IP  - 3
DP  - 2015 Sep
TI  - Antibodies to HLA Molecules Mimic Agonistic Stimulation to Trigger Vascular Cell 
      Changes and Induce Allograft Injury.
PG  - 222-232
LID - 10.1007/s40472-015-0065-6 [doi]
AB  - Human leukocyte antigen (HLA)-induced signaling in endothelial and smooth muscle 
      cells causes dramatic cytoskeletal rearrangement, increased survival, motility, 
      proliferation, adhesion molecule and chemokine expression, and adhesion of 
      leukocytes. These mechanisms are directly related to endothelial activation, 
      neointimal proliferation, and intragraft accumulation of leukocytes during 
      antibody-mediated rejection (AMR) and chronic rejection. Clustering of HLA by 
      ligands in trans, such as in antigen-presenting cells at the immune synapse, 
      triggers physiological functions analogous to HLA antibody-induced signaling in 
      vascular cells. Emerging evidence has revealed previously unknown functions for 
      HLA beyond antigen presentation, including association with coreceptors in cis to 
      permit signal transduction, and modulation of intracellular signaling downstream 
      of other receptors that may be relevant to HLA signaling in the graft 
      vasculature. We discuss the literature regarding HLA-induced signaling in 
      vascular endothelial and smooth muscle cells, as well as under endogenous 
      biological conditions, and how such signaling relates to functional changes and 
      pathological mechanisms during graft injury.
FAU - Valenzuela, Nicole M
AU  - Valenzuela NM
AD  - UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, 
      David Geffen School of Medicine, University of California, 1000 Veteran Ave Room 
      1-520, Los Angeles, CA 90095, USA.
FAU - Reed, Elaine F
AU  - Reed EF
AD  - UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, 
      David Geffen School of Medicine, University of California, 1000 Veteran Ave Room 
      1-520, Los Angeles, CA 90095, USA.
LA  - eng
GR  - R01 AI042819/AI/NIAID NIH HHS/United States
GR  - R56 AI042819/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20150524
PL  - Switzerland
TA  - Curr Transplant Rep
JT  - Current transplantation reports
JID - 101624626
PMC - PMC5365147
MID - NIHMS694151
OTO - NOTNLM
OT  - Antibody-mediated rejection
OT  - Endothelial cells
OT  - HLA antibodies
OT  - Leukocyte recruitment
OT  - Mammalian target of rapamycin (mTOR)
OT  - Signal transduction
EDAT- 2015/09/01 00:00
MHDA- 2015/09/01 00:01
PMCR- 2017/03/24
CRDT- 2017/03/28 06:00
PHST- 2017/03/28 06:00 [entrez]
PHST- 2015/09/01 00:00 [pubmed]
PHST- 2015/09/01 00:01 [medline]
PHST- 2017/03/24 00:00 [pmc-release]
AID - 10.1007/s40472-015-0065-6 [doi]
PST - ppublish
SO  - Curr Transplant Rep. 2015 Sep;2(3):222-232. doi: 10.1007/s40472-015-0065-6. Epub 
      2015 May 24.