PMID- 28345520 OWN - NLM STAT- MEDLINE DCOM- 20190826 LR - 20190826 IS - 2468-7855 (Electronic) IS - 2468-7855 (Linking) VI - 118 IP - 2 DP - 2017 Apr TI - [Management of patients with bradykinin-mediated angioedema in oral and maxillofacial surgery]. PG - 109-114 LID - S2468-7855(17)30034-4 [pii] LID - 10.1016/j.jormas.2017.02.005 [doi] AB - Bradykinin-mediated angioedema (AE) is a rare disease characterized by recurrent cutaneous or mucosal angioedema. This hereditary or acquired disease is of rapid installation, non-pruritic, usually painless and can affect the face, lips, larynx, gastrointestinal tract or extremities. When the affected area involves the upper respiratory tract, laryngeal angioedema can lead to imminent death by asphyxia. This is the reason for the high mortality rate (30 %) in undiagnosed or improperly managed patients. High-risk situations in oral and maxillofacial surgery procedures should be identified preoperatively. Short-term prophylaxis must be carried-out prior to any procedure that may trigger an attack. A multi-site reference center (CREAK) has been created to help clinicians to manage this disease. This article reviews the pathophysiologic mechanisms, the clinical presentations, the possible treatments, the acute strategies for attacks and different prophylactic possibilities in oral and maxillofacial surgery. CI - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved. FAU - Rohart, J AU - Rohart J AD - Service d'odontologie, hopital Saint-Julien, CHU de Rouen, 76031 Rouen, France; UDSL, universite Lille Nord de France, 59000 Lille, France. Electronic address: justine.rohart04@gmail.com. FAU - Bouillet, L AU - Bouillet L AD - Centre national de reference des angioedemes, CHU de Grenoble, 38043 Grenoble cedex 09, France; Centre de reference des angioedemes, clinique universitaire de medecine interne, CHU de Grenoble, 38043 Grenoble cedex 09, France; Unite Inserm 1036, CEA-Grenoble, universite Grenoble-Alpes, 38054 Grenoble cedex 09, France. FAU - Moizan, H AU - Moizan H AD - Service d'odontologie, hopital Saint-Julien, CHU de Rouen, 76031 Rouen, France. LA - fre PT - Journal Article PT - Review TT - Prise en charge des patients atteints d'angioedemes bradykiniques en chirurgie orale et maxillo-faciale. DEP - 20170222 PL - France TA - J Stomatol Oral Maxillofac Surg JT - Journal of stomatology, oral and maxillofacial surgery JID - 101701089 RN - S8TIM42R2W (Bradykinin) MH - Angioedema/classification/*etiology/*therapy MH - Angioedemas, Hereditary/complications/therapy MH - Asphyxia/etiology/therapy MH - Bradykinin/*adverse effects MH - Esophageal Diseases/etiology/therapy MH - Gastrointestinal Diseases/etiology/therapy MH - Humans MH - Oral Surgical Procedures/*methods OTO - NOTNLM OT - Angioedema OT - Angioedeme OT - Bradykinin OT - Bradykinine OT - Chirurgie OT - Maxillo-faciale OT - Maxillofacial surgery OT - Oral OT - Orale EDAT- 2017/03/28 06:00 MHDA- 2019/08/27 06:00 CRDT- 2017/03/28 06:00 PHST- 2016/03/10 00:00 [received] PHST- 2017/01/06 00:00 [revised] PHST- 2017/02/17 00:00 [accepted] PHST- 2017/03/28 06:00 [pubmed] PHST- 2019/08/27 06:00 [medline] PHST- 2017/03/28 06:00 [entrez] AID - S2468-7855(17)30034-4 [pii] AID - 10.1016/j.jormas.2017.02.005 [doi] PST - ppublish SO - J Stomatol Oral Maxillofac Surg. 2017 Apr;118(2):109-114. doi: 10.1016/j.jormas.2017.02.005. Epub 2017 Feb 22.