PMID- 28346397
OWN - NLM
STAT- MEDLINE
DCOM- 20180219
LR  - 20181113
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 7
IP  - 2
DP  - 2017 Mar 27
TI  - The Process and Regulatory Components of Inflammation in Brain Oncogenesis.
LID - 10.3390/biom7020034 [doi]
LID - 34
AB  - Central nervous system tumors comprising the primary cancers and brain metastases 
      remain the most lethal neoplasms and challenging to treat. Substantial evidence 
      points to a paramount role for inflammation in the pathology leading to 
      gliomagenesis, malignant progression and tumor aggressiveness in the central 
      nervous system (CNS) microenvironment. This review summarizes the salient 
      contributions of oxidative stress, interleukins, tumor necrosis factor-alpha (TNF-alpha), 
      cyclooxygenases, and transcription factors such as signal transducer and 
      activator of transcription 3 (STAT3) and nuclear factor 
      kappa-light-chain-enhancer of activated B-cells (NF-kappaB) and the associated 
      cross-talks to the inflammatory signaling in CNS cancers. The roles of reactive 
      astrocytes, tumor associated microglia and macrophages, metabolic alterations, 
      microsatellite instability, O(6)-methylguanine DNA methyltransferase (MGMT) DNA 
      repair and epigenetic alterations mediated by the isocitrate dehydrogenase 1 
      (IDH1) mutations have been discussed. The inflammatory pathways with relevance to 
      the brain cancer treatments have been highlighted.
FAU - Mostofa, A G M
AU  - Mostofa AG
AD  - Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX 
      79106, USA. agm.mostofa@ttuhsc.edu.
FAU - Punganuru, Surendra R
AU  - Punganuru SR
AD  - Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX 
      79106, USA. Surendra.r.punganuru@ttuhsc.edu.
FAU - Madala, Hanumantha Rao
AU  - Madala HR
AD  - Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX 
      79106, USA. hanumantharao.madala@ttuhsc.edu.
FAU - Al-Obaide, Mohammad
AU  - Al-Obaide M
AD  - Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX 
      79106, USA. Mohammad.al-obaide@ttuhsc.edu.
FAU - Srivenugopal, Kalkunte S
AU  - Srivenugopal KS
AD  - Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, 
      Texas Tech University Health Sciences Center, 1406 S. Coulter St., Amarillo, TX 
      79106, USA. Kalkunte.Srivenugopal@ttuhsc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170327
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/complications/drug therapy/immunology/*pathology
MH  - *Carcinogenesis
MH  - Cytokines/metabolism
MH  - Humans
MH  - Inflammation/complications
MH  - Macrophages/immunology
MH  - Tumor Microenvironment
PMC - PMC5485723
OTO - NOTNLM
OT  - MGMT DNA repair
OT  - STAT3
OT  - epigenetic deregulation
OT  - gliomas
OT  - inflammation
OT  - interleukins
COIS- The authors declare no conflict of interest.
EDAT- 2017/03/28 06:00
MHDA- 2018/02/20 06:00
PMCR- 2017/06/01
CRDT- 2017/03/28 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/03/09 00:00 [revised]
PHST- 2017/03/22 00:00 [accepted]
PHST- 2017/03/28 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/02/20 06:00 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - biom7020034 [pii]
AID - biomolecules-07-00034 [pii]
AID - 10.3390/biom7020034 [doi]
PST - epublish
SO  - Biomolecules. 2017 Mar 27;7(2):34. doi: 10.3390/biom7020034.