PMID- 28346888
OWN - NLM
STAT- MEDLINE
DCOM- 20180116
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 253
DP  - 2017 Jul
TI  - Oxidative and nitrosative stress biomarkers in chronic schizophrenia.
PG  - 43-48
LID - S0165-1781(16)31296-3 [pii]
LID - 10.1016/j.psychres.2017.03.038 [doi]
AB  - There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by 
      specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There 
      are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, 
      this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 
      outpatients with SCZ and 118 controls were enrolled. The markers included lipid 
      hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide 
      metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and 
      paraoxonase 1 (PON-1) activity. Immune-inflammatory markers known to be altered 
      in SCZ were also measured: leptin, IL-6, soluble TNF receptors (sTNF-Rs) and the 
      chemokines CCL-11 and CCL-3. There were no significant associations between 
      chronic SCZ and the O&NS markers (AOPP, NOx, LOOH) and the anti-oxidants PON-1 
      and TRAP. Leptin, sTNF-R, CCL-3 and CCL-11 were significantly higher in SCZ. 
      There were significant associations between pro-inflammatory and O&NS biomarkers 
      (leptin/CCL-8 and AOPP; IL-6 and NOx; CCL-3 and LOOH; CCL-3/IL-6/NOx and TRAP). 
      In conclusion, there were significant intercorrelations between inflammatory and 
      O&NS pathways, which play a role in the pathophysiology of chronic SCZ. O&NS 
      markers and the enzyme PON-1 are not useful as biomarkers in chronic stable 
      polymedicated SCZ patients.
CI  - Copyright (c) 2017 Elsevier Ireland Ltd. All rights reserved.
FAU - Boll, Karine Maria
AU  - Boll KM
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil.
FAU - Noto, Cristiano
AU  - Noto C
AD  - First Episode Psychosis Program, Faculdade de Ciencias Medicas da Santa Casa de 
      Sao Paulo, Sao Paulo, SP, Brazil; Schizophrenia Program (PROESQ), Universidade 
      Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Bonifacio, Kamila Landucci
AU  - Bonifacio KL
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil.
FAU - Bortolasci, Chiara Cristina
AU  - Bortolasci CC
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil.
FAU - Gadelha, Ary
AU  - Gadelha A
AD  - Schizophrenia Program (PROESQ), Universidade Federal de Sao Paulo, Sao Paulo, SP, 
      Brazil.
FAU - Bressan, Rodrigo Affonseca
AU  - Bressan RA
AD  - Schizophrenia Program (PROESQ), Universidade Federal de Sao Paulo, Sao Paulo, SP, 
      Brazil.
FAU - Barbosa, Decio Sabbatini
AU  - Barbosa DS
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil.
FAU - Maes, Michael
AU  - Maes M
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil; Department of Psychiatry, Chulalongkorn University, 
      Bangkok, Thailand; IMPACT Strategic Research Center, Deakin University, Geelong, 
      Australia; Revitalis, Waalre, the Netherlands; Department of Psychiatry, Medical 
      University of Plovdiv, Plovdiv, Bulgaria. Electronic address: 
      dr.michaelmaes@hotmail.com.
FAU - Moreira, Estefania Gastaldello
AU  - Moreira EG
AD  - Graduation Program in Health Sciences, Universidade Estadual de Londrina, 
      Londrina, PR, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170321
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
EIN - Psychiatry Res. 2019 Mar;273:809. PMID: 31185578
MH  - Adult
MH  - Antioxidants/analysis
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/blood
MH  - Nitrosative Stress/*physiology
MH  - Oxidative Stress/*physiology
MH  - Schizophrenia/*blood
EDAT- 2017/03/28 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/03/28 06:00
PHST- 2016/08/05 00:00 [received]
PHST- 2017/01/30 00:00 [revised]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/03/28 06:00 [entrez]
AID - S0165-1781(16)31296-3 [pii]
AID - 10.1016/j.psychres.2017.03.038 [doi]
PST - ppublish
SO  - Psychiatry Res. 2017 Jul;253:43-48. doi: 10.1016/j.psychres.2017.03.038. Epub 
      2017 Mar 21.