PMID- 28347828
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180326
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 205
DP  - 2017 Jun 9
TI  - Protective effects of Cinnamomum cassia (Lamaceae) against gout and septic 
      responses via attenuation of inflammasome activation in experimental models.
PG  - 173-177
LID - S0378-8741(16)32278-4 [pii]
LID - 10.1016/j.jep.2017.03.043 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum cassia (C. cassia, Lauraceae family), 
      commonly used for treating dyspepsia, gastritis, blood circulation, and 
      inflammatory diseases is considered as one of the 50 fundamental herbs in 
      traditional Chinese medicine. AIM OF THE STUDY: The anti-inflammatory action of 
      an ethanol extract of C. cassia (CA), and its underlying mechanisms were explored 
      in both in vitro cellular and in vivo murine models. MATERIALS AND METHODS: Bone 
      marrow-derived macrophages (BMDMs) were used to study the regulatory effect of CA 
      on inflammasome activation. A lipopolysaccharide (LPS)-induced sepsis mouse model 
      and a monosodium urate (MSU)-induced gout model were employed to study the effect 
      of CA on in vivo efficacy. RESULTS: CA improved the survival rate in the 
      LPS-induced septic shock mouse model and inhibited inflammasome activation 
      including NLRP3, NLRC4, and AIM2, leading to suppression of interleukin-1beta 
      secretion. Further, ASC oligomerization and its speck formation in cytosol were 
      attenuated by CA treatment. Furthermore, CA improved both survival rate of 
      LPS-induced septic shock and gout murine model. CONCLUSIONS: CA treatment 
      significantly attenuated danger signals-induced inflammatory responses via 
      regulation of inflammasome activation, substantiating the traditional claims of 
      its use in the treatment of inflammation-related disorders.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Shin, Woo-Young
AU  - Shin WY
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Shim, Do-Wan
AU  - Shim DW
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Kim, Myong-Ki
AU  - Kim MK
AD  - Department of Food Science and Engineering, Seowon University, Cheongju, Korea.
FAU - Sun, Xiao
AU  - Sun X
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Koppula, Sushruta
AU  - Koppula S
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Yu, Sang-Hyeun
AU  - Yu SH
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Kim, Han-Bi
AU  - Kim HB
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Kim, Tack-Joong
AU  - Kim TJ
AD  - Division of Biological Science and Technology, Institute of Biomaterials, Yonsei 
      University, Wonju, Korea.
FAU - Kang, Tae-Bong
AU  - Kang TB
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea.
FAU - Lee, Kwang-Ho
AU  - Lee KH
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, Korea. Electronic 
      address: kwangho@kku.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170324
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Inflammasomes)
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Animals
MH  - Cinnamomum aromaticum/*chemistry
MH  - Drugs, Chinese Herbal/chemistry/*pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Gout
MH  - Inflammasomes/*drug effects
MH  - Lipopolysaccharides/toxicity
MH  - Macrophages/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Sepsis/chemically induced/drug therapy
OTO - NOTNLM
OT  - ASC
OT  - Cinnamomum cassia
OT  - Gout
OT  - Inflammasome
OT  - Sepsis
EDAT- 2017/03/30 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/03/29 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/03/23 00:00 [revised]
PHST- 2017/03/23 00:00 [accepted]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/03/29 06:00 [entrez]
AID - S0378-8741(16)32278-4 [pii]
AID - 10.1016/j.jep.2017.03.043 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2017 Jun 9;205:173-177. doi: 10.1016/j.jep.2017.03.043. Epub 
      2017 Mar 24.