PMID- 28348623
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Involvement of Normalized Glial Fibrillary Acidic Protein Expression in the 
      Hippocampi in Antidepressant-Like Effects of Xiaoyaosan on Chronically Stressed 
      Mice.
PG  - 1960584
LID - 10.1155/2017/1960584 [doi]
LID - 1960584
AB  - The research has only yielded a partial comprehension of MDD and the mechanisms 
      underlying the antidepressant-like effects of XYS. Therefore, in this study, we 
      aimed to explore the effects of XYS on chronic unpredictable mild stress- (CUMS-) 
      induced changes in the neuronal and the astrocytic markers in the mouse 
      hippocampus. The physical states and depressive-like behaviors in mice with CUMS 
      were recorded. The serum contents of brain-derived neurotrophic factor (BDNF) and 
      glial cell line-derived neurotrophic factor (GDNF) were measured. The protein and 
      mRNA expressions and the immunoreactivities of glial fibrillary acidic protein 
      (GFAP) and neuronal nuclei (NeuN) in mouse hippocampus were detected using a 
      Western blot, qRT-PCR, and immunohistochemical staining, respectively. XYS 
      treatment markedly improved the physical state and depressive-like behaviors in 
      mice subjected to CUMS compared with the model group, and the serum contents of 
      BDNF and GDNF were significantly upregulated. XYS treatment also elevated the 
      protein and mRNA levels, as well as the immunoreactivity of GFAP in the 
      hippocampus. However, CUMS did not influence NeuN expression. In conclusion, 
      these results reveal that chronic administration of XYS elicits 
      antidepressant-like effects in a mouse model of depression and may normalize 
      glial fibrillary acidic protein expression in the hippocampi of mice with CUMS.
FAU - Ding, Xiu-Fang
AU  - Ding XF
AUID- ORCID: 0000-0001-5513-6202
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - Henan University of Chinese Medicine, Henan, China; School of Pre-Clinical 
      Medicine, Hubei University of Chinese Medicine, Wuhan, China.
FAU - Yan, Zhi-Yi
AU  - Yan ZY
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Li, Xiao-Juan
AU  - Li XJ
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Ma, Qing-Yu
AU  - Ma QY
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Jin, Zhong-Ye
AU  - Jin ZY
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Liu, Yan
AU  - Liu Y
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Li, Yue-Hua
AU  - Li YH
AD  - Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
FAU - Liu, Yue-Yun
AU  - Liu YY
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Xue, Zhe
AU  - Xue Z
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Chen, Jia-Xu
AU  - Chen JX
AUID- ORCID: 0000-0002-5570-6233
AD  - School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 
      100029, China.
FAU - Lv, Zhi-Ping
AU  - Lv ZP
AUID- ORCID: 0000-0003-2796-526X
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 
      Guangdong, China.
LA  - eng
PT  - Journal Article
DEP - 20170302
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5352892
COIS- The authors declare that they have no competing interests.
EDAT- 2017/03/30 06:00
MHDA- 2017/03/30 06:01
PMCR- 2017/03/02
CRDT- 2017/03/29 06:00
PHST- 2016/08/15 00:00 [received]
PHST- 2016/11/29 00:00 [revised]
PHST- 2016/12/26 00:00 [accepted]
PHST- 2017/03/29 06:00 [entrez]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2017/03/30 06:01 [medline]
PHST- 2017/03/02 00:00 [pmc-release]
AID - 10.1155/2017/1960584 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:1960584. doi: 10.1155/2017/1960584. 
      Epub 2017 Mar 2.