PMID- 28349491 OWN - NLM STAT- MEDLINE DCOM- 20180601 LR - 20181113 IS - 1439-0973 (Electronic) IS - 0300-8126 (Print) IS - 0300-8126 (Linking) VI - 45 IP - 5 DP - 2017 Oct TI - Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study. PG - 669-676 LID - 10.1007/s15010-017-1000-9 [doi] AB - There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations. FAU - Janssen, S AU - Janssen S AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. s.janssen@amc.nl. AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. s.janssen@amc.nl. AD - Centre de Traitement Ambulatoire Lambarene, Lambarene, Gabon. s.janssen@amc.nl. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. s.janssen@amc.nl. AD - Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. s.janssen@amc.nl. AD - Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. s.janssen@amc.nl. FAU - Osbak, K AU - Osbak K AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. AD - Centre de Traitement Ambulatoire Lambarene, Lambarene, Gabon. FAU - Holman, R AU - Holman R AD - Clinical Research Unit, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. FAU - Hermans, S AU - Hermans S AD - Department of Global Health, Academic Medical Center, Amsterdam Institute for Global Health and Development, University of Amsterdam, Amsterdam, The Netherlands. AD - Faculty of Health Sciences, Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. AD - Department of Internal Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Moekotte, A AU - Moekotte A AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. FAU - Knap, M AU - Knap M AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. FAU - Rossatanga, E AU - Rossatanga E AD - Centre de Traitement Ambulatoire Lambarene, Lambarene, Gabon. FAU - Massinga-Loembe, M AU - Massinga-Loembe M AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. FAU - Alabi, A AU - Alabi A AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. FAU - Adegnika, A AU - Adegnika A AD - Centre de Traitement Ambulatoire Lambarene, Lambarene, Gabon. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. FAU - Meenken, C AU - Meenken C AD - Department of Ophthalmology, VU Medical Center, Vrije Universiteit, Amsterdam, The Netherlands. FAU - van Vugt, M AU - van Vugt M AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. FAU - Kremsner, P G AU - Kremsner PG AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. FAU - Meintjes, G AU - Meintjes G AD - Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. FAU - van der Poll, T AU - van der Poll T AD - Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. FAU - Grobusch, M P AU - Grobusch MP AD - Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands. AD - Centre de Recherches Medicales en Lambarene, Lambarene, Gabon. AD - Institute of Tropical Medicine, University of Tubingen, Tubingen, Germany. AD - Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa. LA - eng PT - Journal Article DEP - 20170327 PL - Germany TA - Infection JT - Infection JID - 0365307 RN - 0 (Anti-Retroviral Agents) SB - IM MH - Adult MH - Anti-Retroviral Agents/*adverse effects MH - Female MH - Gabon/epidemiology MH - HIV Infections/*drug therapy MH - Humans MH - Immune Reconstitution Inflammatory Syndrome/chemically induced/*epidemiology/etiology/immunology MH - Incidence MH - Male MH - Middle Aged MH - Prospective Studies MH - Tuberculosis/complications PMC - PMC5630650 OTO - NOTNLM OT - AIDS OT - HIV OT - Opportunistic infections OT - Tuberculosis COIS- The authors declare that they have no conflict of interest. EDAT- 2017/03/30 06:00 MHDA- 2018/06/02 06:00 PMCR- 2017/03/27 CRDT- 2017/03/29 06:00 PHST- 2017/02/16 00:00 [received] PHST- 2017/02/21 00:00 [accepted] PHST- 2017/03/30 06:00 [pubmed] PHST- 2018/06/02 06:00 [medline] PHST- 2017/03/29 06:00 [entrez] PHST- 2017/03/27 00:00 [pmc-release] AID - 10.1007/s15010-017-1000-9 [pii] AID - 1000 [pii] AID - 10.1007/s15010-017-1000-9 [doi] PST - ppublish SO - Infection. 2017 Oct;45(5):669-676. doi: 10.1007/s15010-017-1000-9. Epub 2017 Mar 27.