PMID- 28349674
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20180917
IS  - 2041-1626 (Electronic)
IS  - 2041-1618 (Linking)
VI  - 9
IP  - 1
DP  - 2018 Feb
TI  - Association between specific periodontal pathogens, Toll-like receptor-4, and 
      nuclear factor-kappaB expression in placental tissues of pre-eclamptic women with 
      periodontitis.
LID - 10.1111/jicd.12265 [doi]
AB  - AIM: The aim of the present study was to determine the association between the 
      presence of specific periodontal pathogens, Toll-like receptor-4 (TLR-4), and 
      nuclear factor-kappaB (NF-kappaB) expression in the placental tissues of pre-eclamptic 
      women. METHODS: Antenatal periodontal screening was performed in 25 normotensive 
      pregnant women and 25 pre-eclamptic women. Subgingival plaque and placental 
      tissue samples were collected from both groups and screened for the presence of 
      Porphyromonas gingivalis (P. gingivalis), Tannerella forsythia, Aggregatibacter 
      actinomycetemcomitans, and Prevotella intermedia (P. intermedia) using real-time 
      polymerase chain reaction. The placental samples were also analyzed to quantify 
      TLR-4 and NF-kappaB expression. RESULTS: The subgingival plaque samples of 
      pre-eclamptic women showed significantly higher frequencies of P. intermedia. In 
      the placental samples, P. gingivalis, P. intermedia, and the expression of TLR-4 
      and NF-kappaB were found to be at significantly higher levels compared to 
      normotensive pregnant women. Using linear regression analysis, the expression of 
      TLR-4 was significantly influenced by the presence of P. gingivalis 
      (coefficient=3.176, 95% confidence interval [CI]: 367-5.986) and P. intermedia 
      (coefficient=2.886, 95% CI: 0.77-5.696), whereas NF-kappaB expression was influenced 
      only by the presence of P. intermedia (coefficient=2.220, 95% CI: 0.051-4.388) in 
      the placental tissues of pre-eclamptic women. CONCLUSION: An association exists 
      between P. gingivalis and P. intermedia with increased TLR-4 and NF-kappaB expression 
      in the placenta of pre-eclamptic women with periodontitis.
CI  - (c) 2017 John Wiley & Sons Australia, Ltd.
FAU - Parthiban, Prathahini S
AU  - Parthiban PS
AD  - Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, 
      India.
FAU - Mahendra, Jaideep
AU  - Mahendra J
AD  - Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, 
      India.
FAU - Logaranjani, Anitha
AU  - Logaranjani A
AD  - Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, 
      India.
FAU - Shanmugam, Sambandham
AU  - Shanmugam S
AD  - Department of Genetics, University of Madras, Chennai, India.
FAU - Balakrishnan, Anandan
AU  - Balakrishnan A
AD  - Department of Genetics, University of Madras, Chennai, India.
FAU - Junaid, Mohammed
AU  - Junaid M
AD  - Department of Public Health Dentistry, Meenakshi Ammal Dental College and 
      Hospital, Chennai, India.
FAU - Namasivayam, Ambalavanan
AU  - Namasivayam A
AD  - Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20170327
PL  - Australia
TA  - J Investig Clin Dent
JT  - Journal of investigative and clinical dentistry
JID - 101524471
RN  - 0 (DNA, Bacterial)
RN  - 0 (NF-kappa B)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adult
MH  - Aggregatibacter actinomycetemcomitans/genetics/immunology/isolation & 
      purification
MH  - Case-Control Studies
MH  - DNA, Bacterial/genetics/isolation & purification
MH  - Dental Plaque/immunology/microbiology
MH  - Female
MH  - Humans
MH  - NF-kappa B/*biosynthesis/immunology
MH  - Periodontitis/*immunology/*microbiology
MH  - Placenta/*immunology
MH  - Porphyromonas gingivalis/genetics/immunology/isolation & purification
MH  - Pre-Eclampsia/*immunology/*microbiology
MH  - Pregnancy
MH  - Prevotella intermedia/genetics/immunology/isolation & purification
MH  - Tannerella forsythia/genetics/immunology/isolation & purification
MH  - Toll-Like Receptor 4/*biosynthesis/immunology
MH  - Young Adult
OTO - NOTNLM
OT  - Toll-like receptor
OT  - nuclear factor-kappaB
OT  - periodontitis
OT  - placenta
OT  - pre-eclampsia
EDAT- 2017/03/30 06:00
MHDA- 2018/09/18 06:00
CRDT- 2017/03/29 06:00
PHST- 2016/08/16 00:00 [received]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2017/03/29 06:00 [entrez]
AID - 10.1111/jicd.12265 [doi]
PST - ppublish
SO  - J Investig Clin Dent. 2018 Feb;9(1). doi: 10.1111/jicd.12265. Epub 2017 Mar 27.