PMID- 28349870
OWN - NLM
STAT- MEDLINE
DCOM- 20170719
LR  - 20181202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 141
DP  - 2017 Jul
TI  - Improvement of cyanobacterial-killing biologically derived substances (BDSs) 
      using an ecologically safe and cost-effective naphthoquinone derivative.
PG  - 188-198
LID - S0147-6513(17)30069-6 [pii]
LID - 10.1016/j.ecoenv.2017.02.006 [doi]
AB  - In previous studies, naphthoquinone (NQ) compounds have been shown to be 
      effective, selective, and ecologically safe algicides for controlling harmful 
      algal blooming species (HABs) or winter bloom species, such as Stephanodiscus 
      hantzschii. However, there are no reports on NQ-based algicides for use with 
      cyanobacterial blooming species. In this study, we developed 31 NQ compounds to 
      investigate algicides for mitigating cyanobacterial blooms. In addition, to 
      better apply these compounds in the field, we reduced the number of production 
      steps to develop a cost-effective algicide. In preliminary testing, we screened 
      NQ compounds that showed the best algicidal activity on target cyanobacteria, 
      including Aphanizomenon, Dolichospermum, Microcystis, Oscillatoria, and Nostoc 
      species. The compound NQ 2-0 showed the highest algicidal activity (90%) at a low 
      concentration (>/=1muM) on target algae. These were very limiting algicidal effects 
      of 1microM NQ 2-0 observed against non-target algae, such as diatoms (Stephanodiscus 
      hantzschii, Cyclotella meneghiniana, Synedra acus, and Aulacoseira granulata) or 
      green algae (Cosmarium bioculatum and Scenedesmus quadricauda), and the effect 
      did not exceed 15-25% (except against S. quadricauda). NQ 2-0 (1muM) showed no 
      eco-toxicity, as represented by the survival rates of Pseudokirchneriella 
      subcapitata (100%), Daphnia magna (100%), and Danio rerio (100%). Additionally, a 
      chronic eco-toxicity assessment showed no toxicity toward the survival, growth or 
      reproduction of D. magna. Moreover, NQ 2-0 quickly dissipated from field water 
      samples and had a half-life of approximately 3.2 days. These results suggest that 
      NQ 2-0 could be a selective and ecologically safe algicide to mitigate harmful 
      cyanobacterial blooms.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Joo, Jae-Hyoung
AU  - Joo JH
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea.
FAU - Wang, Pengbin
AU  - Wang P
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea.
FAU - Park, Bum Soo
AU  - Park BS
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea.
FAU - Byun, Jeong-Hwan
AU  - Byun JH
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea.
FAU - Choi, Hye Jeong
AU  - Choi HJ
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea.
FAU - Kim, Seong Hun
AU  - Kim SH
AD  - Department of Organic and Nano Engineering, Hanyang University, Seoul 04763, 
      South Korea. Electronic address: kimsh@hanyang.ac.kr.
FAU - Han, Myung-Soo
AU  - Han MS
AD  - Department of Life Science, Hanyang University, Seoul 04763, South Korea; 
      Research Institute for Natural Sciences, Hanyang University, Seoul 04763, South 
      Korea. Electronic address: hanms@hanyang.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170327
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Herbicides)
RN  - 0 (Naphthoquinones)
SB  - IM
MH  - Animals
MH  - Chlorophyta/drug effects/growth & development
MH  - Cyanobacteria/*drug effects/growth & development
MH  - Daphnia/drug effects/growth & development
MH  - Diatoms/drug effects/growth & development
MH  - Ecology
MH  - Half-Life
MH  - Harmful Algal Bloom/*drug effects
MH  - Herbicides/chemistry/*pharmacology/toxicity
MH  - Naphthoquinones/chemistry/*pharmacology/toxicity
MH  - Seasons
MH  - Time Factors
MH  - Toxicity Tests, Acute
MH  - Toxicity Tests, Chronic
OTO - NOTNLM
OT  - Algicide
OT  - Eco-friendly mitigation
OT  - Harmful cyanobacteria blooms
OT  - Naphthoquinone derivatives
EDAT- 2017/03/30 06:00
MHDA- 2017/07/20 06:00
CRDT- 2017/03/29 06:00
PHST- 2016/07/25 00:00 [received]
PHST- 2017/01/06 00:00 [revised]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2017/07/20 06:00 [medline]
PHST- 2017/03/29 06:00 [entrez]
AID - S0147-6513(17)30069-6 [pii]
AID - 10.1016/j.ecoenv.2017.02.006 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2017 Jul;141:188-198. doi: 10.1016/j.ecoenv.2017.02.006. 
      Epub 2017 Mar 27.