PMID- 28351158
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20200328
IS  - 1360-0451 (Electronic)
IS  - 0954-0121 (Print)
IS  - 0954-0121 (Linking)
VI  - 29
IP  - 11
DP  - 2017 Nov
TI  - Stressful and traumatic life events as disruptors to antiretroviral therapy 
      adherence.
PG  - 1378-1385
LID - 10.1080/09540121.2017.1307919 [doi]
AB  - Stressful and traumatic life events (STLEs) are common among HIV-infected 
      individuals and may affect health behaviors such as adherence to antiretroviral 
      (ARV) therapy, with important implications for treatment outcomes. We examined 
      the association between STLEs and ARV adherence among 289 US-based participants 
      enrolled between 7/1/2010 and 9/1/2013 in a study of depression treatment for 
      HIV-infected patients. Participants received monthly telephone calls to assess 
      STLEs and pill count-based ARV adherence. Inverse probability of observation 
      weighting was combined with multiple imputation to address missing data. 
      Participants were mostly male (71%) and black (63%), with a median age of 45 
      years. Median monthly adherence was 96% (interquartile range (IQR): 85-100%). 
      Participants experienced a mean of 2.48 STLEs (range: 0-14) in the previous 
      month. The presence of >/=2 STLEs was associated with a mean change in adherence of 
      -3.67% (95% confidence interval (CI): -7.12%, -0.21%) and decreased likelihood of 
      achieving >/=95% adherence (risk ratio (95% CI) = 0.82 (0.71, 0.95)). For each 
      additional STLE, the mean adherence change was -0.90% (95% CI: -1.79%, 0.00%). 
      STLEs were associated with poorer ARV adherence, including decreased likelihood 
      of adhering to >/=95% of ARV doses. This level of adherence has a critical role in 
      regimen effectiveness and prevention of resistance.
FAU - O'Donnell, Julie K
AU  - O'Donnell JK
AD  - a Department of Epidemiology , Gillings School of Global Public Health, 
      University of North Carolina , Chapel Hill , USA.
FAU - Gaynes, Bradley N
AU  - Gaynes BN
AD  - b Department of Psychiatry , University of North Carolina, School of Medicine , 
      Chapel Hill , USA.
FAU - Cole, Stephen R
AU  - Cole SR
AD  - a Department of Epidemiology , Gillings School of Global Public Health, 
      University of North Carolina , Chapel Hill , USA.
FAU - Edmonds, Andrew
AU  - Edmonds A
AD  - a Department of Epidemiology , Gillings School of Global Public Health, 
      University of North Carolina , Chapel Hill , USA.
FAU - Thielman, Nathan M
AU  - Thielman NM
AD  - c Center for Health Policy , Duke Global Health Institute, Duke University , 
      Durham , USA.
FAU - Quinlivan, E Byrd
AU  - Quinlivan EB
AD  - d Institute for Global Health and Infectious Diseases , Center for AIDS Research, 
      University of North Carolina , Chapel Hill , USA.
FAU - Heine, Amy
AU  - Heine A
AD  - e Institute for Global Health and Infectious Diseases , University of North 
      Carolina , Chapel Hill , USA.
FAU - Modi, Rhiddi
AU  - Modi R
AD  - f Division of Infectious Diseases , University of Alabama, Birmingham School of 
      Medicine , Birmingham , USA.
FAU - Pence, Brian W
AU  - Pence BW
AD  - a Department of Epidemiology , Gillings School of Global Public Health, 
      University of North Carolina , Chapel Hill , USA.
LA  - eng
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
GR  - R01 MH086362/MH/NIMH NIH HHS/United States
GR  - T32 AI070114/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20170328
PL  - England
TA  - AIDS Care
JT  - AIDS care
JID - 8915313
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-HIV Agents/*therapeutic use
MH  - Female
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Life Change Events
MH  - Male
MH  - Medication Adherence/*psychology/*statistics & numerical data
MH  - Middle Aged
MH  - Odds Ratio
MH  - Stress, Psychological/*complications/psychology
MH  - Treatment Outcome
MH  - United States
MH  - Young Adult
PMC - PMC6538389
MID - NIHMS1025843
OTO - NOTNLM
OT  - Antiretroviral
OT  - HIV
OT  - medication adherence
OT  - mental health
OT  - stressful events
COIS- Conflicts of interest: none
EDAT- 2017/03/30 06:00
MHDA- 2018/02/06 06:00
PMCR- 2019/05/28
CRDT- 2017/03/30 06:00
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2017/03/30 06:00 [entrez]
PHST- 2019/05/28 00:00 [pmc-release]
AID - 10.1080/09540121.2017.1307919 [doi]
PST - ppublish
SO  - AIDS Care. 2017 Nov;29(11):1378-1385. doi: 10.1080/09540121.2017.1307919. Epub 
      2017 Mar 28.