PMID- 28351901
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20220408
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Print)
IS  - 0009-7322 (Linking)
VI  - 135
IP  - 22
DP  - 2017 May 30
TI  - Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death 
      in Patients With Dilated Cardiomyopathy and Mild and Moderate Left Ventricular 
      Systolic Dysfunction.
PG  - 2106-2115
LID - 10.1161/CIRCULATIONAHA.116.026910 [doi]
AB  - BACKGROUND: Current guidelines only recommend the use of an implantable 
      cardioverter defibrillator in patients with dilated cardiomyopathy for the 
      primary prevention of sudden cardiac death (SCD) in those with a left ventricular 
      ejection fraction (LVEF) <35%. However, registries of out-of-hospital cardiac 
      arrests demonstrate that 70% to 80% of such patients have an LVEF >35%. Patients 
      with an LVEF >35% also have low competing risks of death from nonsudden causes. 
      Therefore, those at high risk of SCD may gain longevity from successful 
      implantable cardioverter defibrillator therapy. We investigated whether late 
      gadolinium enhancement (LGE) cardiovascular magnetic resonance identified 
      patients with dilated cardiomyopathy without severe LV systolic dysfunction at 
      high risk of SCD. METHODS: We prospectively investigated the association between 
      midwall LGE and the prespecified primary composite outcome of SCD or aborted SCD 
      among consecutive referrals with dilated cardiomyopathy and an LVEF >/=40% to our 
      center between January 2000 and December 2011 who did not have a preexisting 
      indication for implantable cardioverter defibrillator implantation. RESULTS: Of 
      399 patients (145 women, median age 50 years, median LVEF 50%, 25.3% with LGE) 
      followed for a median of 4.6 years, 18 of 101 (17.8%) patients with LGE reached 
      the prespecified end point, compared with 7 of 298 (2.3%) without (hazard ratio 
      [HR], 9.2; 95% confidence interval [CI], 3.9-21.8; P<0.0001). Nine patients 
      (8.9%) with LGE compared with 6 (2.0%) without (HR, 4.9; 95% CI, 1.8-13.5; 
      P=0.002) died suddenly, whereas 10 patients (9.9%) with LGE compared with 1 
      patient (0.3%) without (HR, 34.8; 95% CI, 4.6-266.6; P<0.001) had aborted SCD. 
      After adjustment, LGE predicted the composite end point (HR, 9.3; 95% CI, 
      3.9-22.3; P<0.0001), SCD (HR, 4.8; 95% CI, 1.7-13.8; P=0.003), and aborted SCD 
      (HR, 35.9; 95% CI, 4.8-271.4; P<0.001). Estimated HRs for the primary end point 
      for patients with an LGE extent of 0% to 2.5%, 2.5% to 5%, and >5% compared with 
      those without LGE were 10.6 (95% CI, 3.9-29.4), 4.9 (95% CI, 1.3-18.9), and 11.8 
      (95% CI, 4.3-32.3), respectively. CONCLUSIONS: Midwall LGE identifies a group of 
      patients with dilated cardiomyopathy and an LVEF >/=40% at increased risk of SCD 
      and low risk of nonsudden death who may benefit from implantable cardioverter 
      defibrillator implantation. CLINICAL TRIAL REGISTRATION: URL: 
      http://clinicaltrials.gov. Unique identifier: NCT00930735.
CI  - (c) 2017 The Authors.
FAU - Halliday, Brian P
AU  - Halliday BP
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Gulati, Ankur
AU  - Gulati A
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Ali, Aamir
AU  - Ali A
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Guha, Kaushik
AU  - Guha K
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Newsome, Simon
AU  - Newsome S
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Arzanauskaite, Monika
AU  - Arzanauskaite M
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Vassiliou, Vassilios S
AU  - Vassiliou VS
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Lota, Amrit
AU  - Lota A
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Izgi, Cemil
AU  - Izgi C
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Tayal, Upasana
AU  - Tayal U
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Khalique, Zohya
AU  - Khalique Z
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Stirrat, Colin
AU  - Stirrat C
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Auger, Dominique
AU  - Auger D
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Pareek, Nilesh
AU  - Pareek N
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Ismail, Tevfik F
AU  - Ismail TF
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Rosen, Stuart D
AU  - Rosen SD
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Vazir, Ali
AU  - Vazir A
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Alpendurada, Francisco
AU  - Alpendurada F
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Gregson, John
AU  - Gregson J
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Frenneaux, Michael P
AU  - Frenneaux MP
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Cowie, Martin R
AU  - Cowie MR
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Cleland, John G F
AU  - Cleland JGF
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Cook, Stuart A
AU  - Cook SA
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
FAU - Pennell, Dudley J
AU  - Pennell DJ
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.). 
      dj.pennell@rbht.nhs.uk.
FAU - Prasad, Sanjay K
AU  - Prasad SK
AD  - From National Institute for Health Research Cardiovascular Biomedical Research 
      Unit and Cardiovascular Magnetic Resonance Unit (B.P.H., A.G., A.A., M.A., 
      V.S.V., A.L. C.I., U.T. Z.K., D.A., F.A., J.G.F.C., S.A.C., D.J.P., S.K.P.), 
      Department of Cardiology (K.G., N.P., S.D.R., A.V., M.R.C.), Royal Brompton 
      Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial 
      College, London, United Kingdom (B.P.H., A.A., K.G., V.S.V., A.L., U.T., S.D.R., 
      A.V., F.A., M.R.C., J.G.F.C., S.A.C., D.J.P., S.K.P.); London School of Hygiene 
      and Tropical Medicine, United Kingdom (S.N., J.G.); Norwich Medical School, 
      University of East Anglia, United Kingdom (V.S.V., M.P.F); Centre for 
      Cardiovascular Science, University of Edinburgh, United Kingdom (C.S.); King's 
      College London and Department of Cardiology, Guy's and St Thomas' Hospital, 
      London, United Kingdom (T.F.I.); Department of Cardiology, Ealing Hospital, 
      London, United Kingdom (S.D.R.); and National Heart Centre Singapore (S.A.C.).
LA  - eng
SI  - ClinicalTrials.gov/NCT00930735
GR  - FS/15/29/31492/BHF_/British Heart Foundation/United Kingdom
GR  - FS/17/21/32712/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
DEP - 20170328
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Circulation. 2017 May 30;135(22):2116-2118. PMID: 28351902
CIN - Circulation. 2018 Jan 2;137(1):99-100. PMID: 29279344
CIN - Circulation. 2018 Jan 2;137(1):101-102. PMID: 29279345
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/*diagnostic imaging/epidemiology/*mortality
MH  - Death, Sudden, Cardiac/*pathology
MH  - Endothelium, Vascular/diagnostic imaging
MH  - Female
MH  - Follow-Up Studies
MH  - *Gadolinium/administration & dosage
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Stroke Volume/physiology
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/epidemiology/*mortality
PMC - PMC5444425
MID - EMS72243
OTO - NOTNLM
OT  - cardiovascular MRI
OT  - dilated cardiomyopathy
OT  - implantable cardioverter-defibrillator
OT  - late gadolinium enhancement
OT  - sudden cardiac death
EDAT- 2017/03/30 06:00
MHDA- 2017/08/19 06:00
PMCR- 2017/05/25
CRDT- 2017/03/30 06:00
PHST- 2016/12/17 00:00 [received]
PHST- 2017/03/13 00:00 [accepted]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
PHST- 2017/03/30 06:00 [entrez]
PHST- 2017/05/25 00:00 [pmc-release]
AID - CIRCULATIONAHA.116.026910 [pii]
AID - 10.1161/CIRCULATIONAHA.116.026910 [doi]
PST - ppublish
SO  - Circulation. 2017 May 30;135(22):2106-2115. doi: 
      10.1161/CIRCULATIONAHA.116.026910. Epub 2017 Mar 28.