PMID- 28352073
OWN - NLM
STAT- MEDLINE
DCOM- 20180830
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Mar 28
TI  - Periaqueductal Grey differential modulation of Nucleus Accumbens and Basolateral 
      Amygdala plasticity under controllable and uncontrollable stress.
PG  - 487
LID - 10.1038/s41598-017-00562-5 [doi]
LID - 487
AB  - Resilience has been conceptualized in part as a dynamic process that includes the 
      ability to adapt to stressful conditions. As such it encompasses the extent to 
      which neural plasticity may be promoted. The current study examined 
      metaplasticity by referring to the "plasticity of synaptic plasticity" in a 
      neural circuit composed of the basolateral amygdala (BLA) and the nucleus 
      accumbens (NAcc), using behavioural stress controllability with or without 
      preceding stimulation of the dorsal periaqueductal gray (i.e. dPAG priming). A 
      tendency for increased plasticity in the controllable versus the uncontrollable 
      group was found in both the BLA and NAcc. dPAG priming suppressed NAcc LTP in all 
      groups, but it suppressed BLA LTP only in the uncontrollable group, demonstrating 
      dissociation between either controllable and uncontrollable groups or the NAcc 
      and BLA. Thus, metaplasticity in the dPAG-BLA-NAcc circuit regulated 
      differentially by controllable or uncontrollable stress may underlie stress 
      coping, and thus contribute to stress-related psychopathologies.
FAU - Horovitz, Omer
AU  - Horovitz O
AD  - Department of Psychology, University of Haifa, Haifa, Israel. 
      horovitz.omer@gmail.com.
FAU - Richter-Levin, Alon
AU  - Richter-Levin A
AD  - Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.
FAU - Xu, Lin
AU  - Xu L
AUID- ORCID: 0000-0002-2710-3507
AD  - Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint 
      Laboratory of Bioresources and Molecular Research in Common Disease, and 
      Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese 
      Academy of Sciences, Kunming, 650223, China.
AD  - University of the Chinese Academy of Sciences, Beijing, 100049, China.
AD  - CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai, 200031, 
      China.
FAU - Jing, Liang
AU  - Jing L
AD  - The Institute for the Study of Affective Neuroscience (ISAN), Haifa, Israel.
AD  - Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint 
      Laboratory of Bioresources and Molecular Research in Common Disease, and 
      Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese 
      Academy of Sciences, Kunming, 650223, China.
FAU - Richter-Levin, Gal
AU  - Richter-Levin G
AD  - Department of Psychology, University of Haifa, Haifa, Israel.
AD  - The Institute for the Study of Affective Neuroscience (ISAN), Haifa, Israel.
AD  - Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170328
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Avoidance Learning
MH  - Basolateral Nuclear Complex/*physiology
MH  - Electric Stimulation
MH  - Electrophysiological Phenomena
MH  - Male
MH  - *Neuronal Plasticity
MH  - Nucleus Accumbens/*physiology
MH  - Periaqueductal Gray/*physiology
MH  - Psychomotor Performance
MH  - Rats
MH  - *Stress, Psychological
PMC - PMC5428674
COIS- The authors declare that they have no competing interests.
EDAT- 2017/03/30 06:00
MHDA- 2018/08/31 06:00
PMCR- 2017/03/28
CRDT- 2017/03/30 06:00
PHST- 2016/09/27 00:00 [received]
PHST- 2017/03/03 00:00 [accepted]
PHST- 2017/03/30 06:00 [entrez]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2018/08/31 06:00 [medline]
PHST- 2017/03/28 00:00 [pmc-release]
AID - 10.1038/s41598-017-00562-5 [pii]
AID - 562 [pii]
AID - 10.1038/s41598-017-00562-5 [doi]
PST - epublish
SO  - Sci Rep. 2017 Mar 28;7(1):487. doi: 10.1038/s41598-017-00562-5.