PMID- 28352224
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1663-3563 (Print)
IS  - 1663-3563 (Electronic)
IS  - 1663-3563 (Linking)
VI  - 9
DP  - 2017
TI  - Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal 
      CA1 Pyramidal Neurons.
PG  - 7
LID - 10.3389/fnsyn.2017.00007 [doi]
LID - 7
AB  - Understanding learning and memory mechanisms is an important goal in 
      neuroscience. To gain insights into the underlying cellular mechanisms for memory 
      formation, synaptic plasticity processes are studied with various techniques in 
      different brain regions. A valid model to scrutinize different ways to enhance or 
      decrease synaptic transmission is recording of long-term potentiation (LTP) or 
      long-term depression (LTD). At the single cell level, spike timing-dependent 
      plasticity (STDP) protocols have emerged as a powerful tool to investigate 
      synaptic plasticity with stimulation paradigms that also likely occur during 
      memory formation in vivo. Such kind of plasticity can be induced by different 
      STDP paradigms with multiple repeat numbers and stimulation patterns. They 
      subsequently recruit or activate different molecular pathways and neuromodulators 
      for induction and expression of STDP. Dopamine (DA) and brain-derived 
      neurotrophic factor (BDNF) have been recently shown to be important modulators 
      for hippocampal STDP at Schaffer collateral (SC)-CA1 synapses and are activated 
      exclusively by distinguishable STDP paradigms. Distinct types of parallel 
      synaptic plasticity in a given neuron depend on specific subcellular molecular 
      prerequisites. Since the basal and apical dendrites of CA1 pyramidal neurons are 
      known to be heterogeneous, and distance-dependent dendritic gradients for 
      specific receptors and ion channels are described, the dendrites might provide 
      domain specific locations for multiple types of synaptic plasticity in the same 
      neuron. In addition to the distinct signaling and expression mechanisms of 
      various types of LTP and LTD, activation of these different types of plasticity 
      might depend on background brain activity states. In this article, we will 
      discuss some ideas why multiple forms of synaptic plasticity can simultaneously 
      and independently coexist and can contribute so effectively to increasing the 
      efficacy of memory storage and processing capacity of the brain. We hypothesize 
      that resolving the subcellular location of t-LTP and t-LTD mechanisms that are 
      regulated by distinct neuromodulator systems will be essential to reach a more 
      cohesive understanding of synaptic plasticity in memory formation.
FAU - Edelmann, Elke
AU  - Edelmann E
AD  - Institute of Physiology, Otto-von-Guericke UniversityMagdeburg, Germany; Center 
      for Behavioral Brain Sciences, Otto-von-Guericke UniversityMagdeburg, Germany.
FAU - Cepeda-Prado, Efrain
AU  - Cepeda-Prado E
AD  - Institute of Physiology, Otto-von-Guericke University Magdeburg, Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institute of Physiology, Otto-von-Guericke UniversityMagdeburg, Germany; Center 
      for Behavioral Brain Sciences, Otto-von-Guericke UniversityMagdeburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170314
PL  - Switzerland
TA  - Front Synaptic Neurosci
JT  - Frontiers in synaptic neuroscience
JID - 101548972
PMC - PMC5348504
OTO - NOTNLM
OT  - BDNF
OT  - dopamine
OT  - excitatory neurons
OT  - hippocampus
OT  - repeat number
OT  - spike timing-dependent plasticity
OT  - synapse specific LTP
OT  - synaptic plasticity
EDAT- 2017/03/30 06:00
MHDA- 2017/03/30 06:01
PMCR- 2017/01/01
CRDT- 2017/03/30 06:00
PHST- 2016/11/14 00:00 [received]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/03/30 06:00 [entrez]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2017/03/30 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnsyn.2017.00007 [doi]
PST - epublish
SO  - Front Synaptic Neurosci. 2017 Mar 14;9:7. doi: 10.3389/fnsyn.2017.00007. 
      eCollection 2017.