PMID- 28353559
OWN - NLM
STAT- MEDLINE
DCOM- 20170406
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 13
DP  - 2017 Mar
TI  - Hyperactivity of the default-mode network in first-episode, drug-naive 
      schizophrenia at rest revealed by family-based case-control and traditional 
      case-control designs.
PG  - e6223
LID - 10.1097/MD.0000000000006223 [doi]
LID - e6223
AB  - Abnormal regional activity and functional connectivity of the default-mode 
      network (DMN) have been reported in schizophrenia. However, previous studies may 
      have been biased by unmatched case-control design. To limit such bias, the 
      present study used both the family-based case-control design and the traditional 
      case-control design to investigate abnormal regional activity of the DMN in 
      patients with schizophrenia at rest.Twenty-eight first-episode, drug-naive 
      patients with schizophrenia, 28 age-, sex-matched unaffected siblings of the 
      patients (family-based controls, FBC), and 40 healthy controls (HC) underwent 
      resting-state functional magnetic resonance imaging (fMRI) scans. The 
      group-independent component analysis and fractional amplitude of low-frequency 
      fluctuation (fALFF) methods were used to analyze the data.Patients with 
      schizophrenia show increased fALFF in an overlapped region of the right superior 
      medial prefrontal cortex (MPFC) relative to the FBC and the HC. Compared with the 
      HC, the patients and the FBC exhibit increased fALFF in an overlapped region of 
      the left posterior cingulate cortex/precuneus (PCC/PCu). Furthermore, the z 
      values of the 2 overlapped regions can separate the patients from the FBC/HC, and 
      separate the patients/FBC from the HC with relatively high sensitivity and 
      specificity.Both the family-based case-control and traditional case-control 
      designs reveal hyperactivity of the DMN in first-episode, drug-naive patients 
      with paranoid schizophrenia, which highlights the importance of the DMN in the 
      neurobiology of schizophrenia. Family-based case-control design can limit the 
      confounding effects of environmental factors in schizophrenia. Combination of the 
      family-based case-control and traditional case-control designs may be a viable 
      option for the neuroimaging studies.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry, the Second Xiangya Hospital, Central South University, 
      Changsha, Hunan Key Laboratory for NeuroInformation of Ministry of Education, 
      School of Life Science and Technology, University of Electronic Science and 
      Technology of China, Chengdu, Sichuan Mental Health Institute of the Second 
      Xiangya Hospital, Central South University, Changsha, Hunan, China Mental Health 
      Institute of the Second Xiangya Hospital, Central South University, Changsha, 
      Hunan Sheng National Clinical Research Center on Mental Disorders, Changsha, 
      Hunan, China National Technology Institute on Mental Disorders, Changsha, Hunan, 
      China Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, Hunan, 
      China.
FAU - Liu, Feng
AU  - Liu F
FAU - Chen, Jindong
AU  - Chen J
FAU - Wu, Renrong
AU  - Wu R
FAU - Li, Lehua
AU  - Li L
FAU - Zhang, Zhikun
AU  - Zhang Z
FAU - Chen, Huafu
AU  - Chen H
FAU - Zhao, Jingping
AU  - Zhao J
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Schizophrenia/diagnostic imaging/*physiopathology
MH  - Young Adult
PMC - PMC5380243
COIS- All the authors announce that they have no conflict of interest.
EDAT- 2017/03/30 06:00
MHDA- 2017/04/07 06:00
PMCR- 2017/03/31
CRDT- 2017/03/30 06:00
PHST- 2017/03/30 06:00 [entrez]
PHST- 2017/03/30 06:00 [pubmed]
PHST- 2017/04/07 06:00 [medline]
PHST- 2017/03/31 00:00 [pmc-release]
AID - 00005792-201703310-00005 [pii]
AID - MD-D-16-04167 [pii]
AID - 10.1097/MD.0000000000006223 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Mar;96(13):e6223. doi: 10.1097/MD.0000000000006223.