PMID- 28356165
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20240324
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 10
IP  - 1
DP  - 2017 Mar 29
TI  - Relationship between hyperglycemia, antioxidant capacity and some enzymatic and 
      non-enzymatic antioxidants in African patients with type 2 diabetes.
PG  - 141
LID - 10.1186/s13104-017-2463-6 [doi]
LID - 141
AB  - BACKGROUND AND PURPOSE: Studies demonstrate that free radicals are involved in 
      the pathogenesis of diabetic complications. The aim of this study was to 
      determine the implication of total antioxidant capacity (TAC) and some enzymatic 
      and non-enzymatic antioxidants as suitable biomarkers of diabetic complications 
      risk factors. METHODS: A total of 90 patients (70 patients with or without 
      diabetic complications +20 normal healthy) were examined by evaluating the level 
      of lipid peroxidation, nitrogen monoxide (NO), fasting blood glucose, glycated 
      haemoglobin (HbA1c), enzymatic and non-enzymatic antioxidants using standard 
      spectrophotometric methods. RESULTS: The fasting blood glucose and HbA1c levels 
      were respectively 2.05 and 2.32 times higher in the group of patients with 
      diabetes and complications (DPWC) compared to those of healthy persons. A 
      statistically higher level of malondialdehyde (MDA), NO and TAC was observed in a 
      group of patients with diabetes and complications compared to those without 
      complications (DPNC). A significant positive correlation was found between 
      catalase (CAT) and fasting blood glucose while a significant and negative 
      correlation was noted between reduced glutathione (GSH) and fasting blood 
      glucose. Also was noted a significant relationship between HbA1c and other 
      markers of oxidative stress. CONCLUSIONS: The results suggest that the plasma 
      levels of CAT, TAC and reduced glutathione could give information on the risk of 
      developing complications of diabetes, considering that the modification of these 
      biomarkers levels were associated with oxidative stress.
FAU - Pieme, Constant Anatole
AU  - Pieme CA
AUID- ORCID: 0000-0003-1602-6494
AD  - Department of Biochemistry and Physiological Sciences; Faculty of Medicine and 
      Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon. 
      apieme@yahoo.fr.
FAU - Tatangmo, Jerome Antony
AU  - Tatangmo JA
AD  - Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 
      67, Dschang, Cameroon.
FAU - Simo, Gustave
AU  - Simo G
AD  - Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 
      67, Dschang, Cameroon.
FAU - Biapa Nya, Prosper Cabral
AU  - Biapa Nya PC
AD  - Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 
      67, Dschang, Cameroon.
FAU - Ama Moor, Vicky Jocelyne
AU  - Ama Moor VJ
AD  - Department of Biochemistry and Physiological Sciences; Faculty of Medicine and 
      Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
FAU - Moukette Moukette, Bruno
AU  - Moukette Moukette B
AD  - Department of Biochemistry and Physiological Sciences; Faculty of Medicine and 
      Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
FAU - Tankeu Nzufo, Francine
AU  - Tankeu Nzufo F
AD  - Department of Biochemistry and Physiological Sciences; Faculty of Medicine and 
      Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
FAU - Njinkio Nono, Borgia Legrand
AU  - Njinkio Nono BL
AD  - Department of Biochemistry, Faculty of Science, University of Yaounde I, P.O. Box 
      812, Yaounde, Cameroon.
FAU - Sobngwi, Eugene
AU  - Sobngwi E
AD  - Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, 
      University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon.
LA  - eng
PT  - Journal Article
DEP - 20170329
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*metabolism
MH  - Biomarkers/*blood
MH  - Blood Glucose/metabolism
MH  - Cameroon
MH  - Catalase/blood
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Fasting/blood
MH  - Female
MH  - Glutathione/blood
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hyperglycemia/*blood/complications
MH  - Lipid Peroxidation
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Nitric Oxide/blood
MH  - Oxidative Stress
MH  - Superoxide Dismutase/blood
PMC - PMC5372257
OTO - NOTNLM
OT  - Malondialdehyde
OT  - Oxidative stress
OT  - Total Antioxidant Capacity
OT  - Type 2 diabetes
EDAT- 2017/03/31 06:00
MHDA- 2017/04/25 06:00
PMCR- 2017/03/29
CRDT- 2017/03/31 06:00
PHST- 2016/06/17 00:00 [received]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/03/31 06:00 [entrez]
PHST- 2017/03/31 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2017/03/29 00:00 [pmc-release]
AID - 10.1186/s13104-017-2463-6 [pii]
AID - 2463 [pii]
AID - 10.1186/s13104-017-2463-6 [doi]
PST - epublish
SO  - BMC Res Notes. 2017 Mar 29;10(1):141. doi: 10.1186/s13104-017-2463-6.