PMID- 28356658
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 0971-4065 (Print)
IS  - 1998-3662 (Electronic)
IS  - 0971-4065 (Linking)
VI  - 27
IP  - 2
DP  - 2017 Mar-Apr
TI  - N-acetyl cysteine versus allopurinol in the prevention of contrast nephropathy in 
      patients with chronic kidney disease: A randomized controlled trial.
PG  - 93-98
LID - 10.4103/0971-4065.194397 [doi]
AB  - Contrast media administration can lead to acute deterioration in renal function 
      particularly in patients with pre-existing chronic kidney disease. This 
      prospective, randomized controlled open-label parallel group study was undertaken 
      at Nizam's Institute of Medical Sciences, Hyderabad, from June to December 2015. 
      A total of 95 patients were included, of which 35 received n-acetylcysteine (NAC) 
      + normal saline (NS), 30 patients received allopurinol (ALL) + NS, and 30 
      patients received placebo. In our study, the overall incidence of CIN was 24%. 
      Incidence of CIN in NAC + NS, ALL + NS, and placebo group were 20%, 16%, and 36%, 
      respectively. The major finding of this study was there was no significant 
      difference between NAC and allopurinol in the prevention of contrast nephropathy. 
      However, only allopurinol was superior to placebo. In our study, hyperuricemia 
      and baseline serum creatinine were the only risk factors associated with CIN.
FAU - Sadineni, R
AU  - Sadineni R
AD  - Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Karthik, K R
AU  - Karthik KR
AD  - Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Swarnalatha, G
AU  - Swarnalatha G
AD  - Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Das, U
AU  - Das U
AD  - Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
FAU - Taduri, G
AU  - Taduri G
AD  - Department of Nephrology, Nizam's Institute of Medical Sciences, Hyderabad, 
      Telangana, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Nephrol
JT  - Indian journal of nephrology
JID - 8914356
PMC - PMC5358166
OTO - NOTNLM
OT  - Allopurinol
OT  - N-acetylcysteine
OT  - chronic kidney disease
OT  - contrast nephropathy
COIS- There are no conflicts of interest.
EDAT- 2017/03/31 06:00
MHDA- 2017/03/31 06:01
PMCR- 2017/03/01
CRDT- 2017/03/31 06:00
PHST- 2017/03/31 06:00 [entrez]
PHST- 2017/03/31 06:00 [pubmed]
PHST- 2017/03/31 06:01 [medline]
PHST- 2017/03/01 00:00 [pmc-release]
AID - IJN-27-93 [pii]
AID - 10.4103/0971-4065.194397 [doi]
PST - ppublish
SO  - Indian J Nephrol. 2017 Mar-Apr;27(2):93-98. doi: 10.4103/0971-4065.194397.