PMID- 28356831
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1452-8258 (Print)
IS  - 1452-8266 (Electronic)
IS  - 1452-8266 (Linking)
VI  - 34
IP  - 2
DP  - 2015 Apr
TI  - Correlation Between Glycated Hemoglobin and Homa Indices in Type 2 Diabetes 
      Mellitus: Prediction of Beta-Cell Function from Glycated Hemoglobin.
PG  - 191-199
LID - 10.2478/jomb-2014-0033 [doi]
AB  - BACKGROUND: The present study aimed to determine the most efficient insulin 
      resistance function related to glycemic control expressed as glycated hemoglobin 
      (HbA1c) in type 2 diabetes mellitus patients (T2DM). The other aim is to derive 
      equations for the prediction of beta cell functions containing HbA1c as a 
      parameter in addition to fasting glucose and insulin. METHODS: T2DM Patients were 
      grouped according to the following: (1) degree of control (good, fair, and poor 
      control) and (2) insulin resistance as observed in obtained data and significant 
      differences revealed by the homeostasis model assessment (HOMA) of related 
      parameters (insulin resistance = HOMA2IR, beta-cell function = HOMA%B, and 
      insulin sensitivity = HOMA%S) among groups. Correlations and forecasting 
      regression analysis were calculated. RESULTS: HbA1c was found to be correlated 
      with insulin resistance parameters in T2DM subgroups. This correlation was also 
      significantly correlated with HOMA%B and the quantitative insulin sensitivity 
      check index (QUICKI) in fair and poor control groups. Regression analysis was 
      used to predict the forecasting equations for HOMA%B. The best applicable 
      equations were derived for healthy control 
      (HOMA2%B=-1.76*FBG+5.00*Insulin+4.69*HbA1c+189.84) and poor control groups 
      (HOMA2%B=0.001* FBG+0.5*Insulin-8.67*HbA1c+101.96). These equations could be used 
      to predict beta-cell function (HOMA%B) after FBG, insulin and HbA1c values were 
      obtained for healthy and poor control groups. In the good and fair control 
      groups, the applicability of the HOMA model fails to yield appropriate results. 
      CONCLUSIONS: Beta-cell function is correlated with QUICKI and HbA1c and could be 
      predicted properly from HbA1c, insulin, and glucose in the healthy and poor 
      control groups. New regression equations were established that involve HbA1c.
FAU - Al-Hakeim, Hussein Kadhem
AU  - Al-Hakeim HK
AD  - College of Science, Kufa University, Iraq.
FAU - Abdulzahra, Mohammed Saied
AU  - Abdulzahra MS
AD  - Dean of the College of Medicine, Kufa University, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20150303
PL  - Serbia
TA  - J Med Biochem
JT  - Journal of medical biochemistry
JID - 101315490
PMC - PMC4922324
OTO - NOTNLM
OT  - Bennett index
OT  - HbA1c
OT  - QUICKI
OT  - insulin resistance
OT  - type 2 diabetes mellitus
EDAT- 2015/04/01 00:00
MHDA- 2015/04/01 00:01
PMCR- 2015/04/01
CRDT- 2017/03/31 06:00
PHST- 2013/12/10 00:00 [received]
PHST- 2014/01/25 00:00 [accepted]
PHST- 2017/03/31 06:00 [entrez]
PHST- 2015/04/01 00:00 [pubmed]
PHST- 2015/04/01 00:01 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - jomb-2014-0033 [pii]
AID - 10.2478/jomb-2014-0033 [doi]
PST - ppublish
SO  - J Med Biochem. 2015 Apr;34(2):191-199. doi: 10.2478/jomb-2014-0033. Epub 2015 Mar 
      3.