PMID- 28356859
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220310
IS  - 1452-8258 (Print)
IS  - 1452-8266 (Electronic)
IS  - 1452-8266 (Linking)
VI  - 35
IP  - 1
DP  - 2016 Jan
TI  - Diagnostic Accuracy of Brain-derived Neurotrophic Factor and Nitric Oxide in 
      Patients with Schizophrenia: A pilot study.
PG  - 7-16
LID - 10.1515/jomb-2015-0010 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) and nitric oxide (NO) play 
      multiple roles in the developing and adult CNS. Since BDNF and NO metabolisms are 
      dysregulated in schizophrenia, we measured these markers simultaneously in the 
      blood of schizophrenics and assessed their diagnostic accuracy. METHODS: 
      Thirty-eight patients with schizophrenia classified according to demographic 
      characteristics, symptomatologyand therapy and 39 age- and gender-matched healthy 
      controls were enrolled. BDNF was determined by the ELISA technique while the 
      concentration of nitrite/nitrate ([Formula: see text]) was measured by the 
      colorimetric method. RESULTS: Serum BDNF levels were significantly lower 
      (20.38+/-3.73 ng/mL, P = 1.339E-05), whilst plasma [Formula: see text] 
      concentrations were significantly higher (84.3 (72-121) mumol/L, P=4.357E-08) in 
      patients with schizophrenia than in healthy controls (25.65+/-4.32 ng/mL; 60.9 
      (50-76) mumol/L, respectively). The lowest value of BDNF (18.14+/-3.26 ng/mL) and 
      the highest [Formula: see text] concentration (115.3 (80-138) mumol/L) were found 
      in patients treated with second-generation antipsychotics (SGA). The patients 
      diseased before the age of 24 and the patients suffering for up to one year had 
      significantly lower serum BDNF levels than those diseased after the age of 24 and 
      the patients who were ill longer than one year. Both BDNF and [Formula: see text] 
      showed good diagnostic accuracy, but BDNF had better ROC curve characteristics, 
      especially in patients with negative symptomatology. CONCLUSIONS: BDNF and 
      nitrite/nitrate showed inverse changes in schizophrenic patients. The most 
      pronounced changes were found in patients treated with second-generation 
      antipsychotics. Although BDNF is not specific of schizophrenia, it may be a 
      clinically useful biomarker for the diagnosis of patients expressing 
      predominantly negative symptoms.
FAU - Djordjevic, Vladimir V
AU  - Djordjevic VV
AD  - Clinic for Mental Health Protection, Clinical Centre Nis, Serbia.
FAU - Lazarevic, Dusan
AU  - Lazarevic D
AD  - Clinic for Psychiatry, Clinical Centre Nis, Serbia.
FAU - Cosic, Vladan
AU  - Cosic V
AD  - Centre for Medical Biochemistry, Clinical Centre Nis, Serbia.
FAU - Knezevic, Marinela Z
AU  - Knezevic MZ
AD  - Department of Neuroscience, University of Kragujevac, Serbia.
FAU - Djordjevic, Vidosava B
AU  - Djordjevic VB
AD  - Institute of Biochemistry, Faculty of Medicine, Nis, Serbia.
FAU - Stojanovic, Ivana
AU  - Stojanovic I
AD  - Institute of Biochemistry, Faculty of Medicine, Nis, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20151230
PL  - Serbia
TA  - J Med Biochem
JT  - Journal of medical biochemistry
JID - 101315490
PMC - PMC5346796
OTO - NOTNLM
OT  - ROC curve
OT  - brain-derived neurotrophic factor
OT  - nitric oxide
OT  - schizophrenia
COIS- The authors stated that they have no conflicts of interest regarding the 
      publication of this article.
EDAT- 2016/01/01 00:00
MHDA- 2016/01/01 00:01
PMCR- 2016/01/01
CRDT- 2017/03/31 06:00
PHST- 2015/01/05 00:00 [received]
PHST- 2015/06/16 00:00 [accepted]
PHST- 2017/03/31 06:00 [entrez]
PHST- 2016/01/01 00:00 [pubmed]
PHST- 2016/01/01 00:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - jomb-2015-0010 [pii]
AID - 10.1515/jomb-2015-0010 [doi]
PST - ppublish
SO  - J Med Biochem. 2016 Jan;35(1):7-16. doi: 10.1515/jomb-2015-0010. Epub 2015 Dec 
      30.