PMID- 2835739
OWN - NLM
STAT- MEDLINE
DCOM- 19880620
LR  - 20061115
IS  - 0890-6467 (Print)
IS  - 0890-6467 (Linking)
VI  - 2
IP  - 3
DP  - 1988 Feb
TI  - Amplification of the int-2 gene in primary human breast tumors.
PG  - 285-91
AB  - Proviral activation of the int-2 gene is a frequent occurrence in mammary 
      carcinomas induced by mouse mammary tumor virus (MMTV). Here, we have examined 
      the human homolog of int-2 in 110 primary breast cancer DNAs. The locus was 
      amplified 2- to 15-fold in 18 of the tumor DNA samples. Amplification of int-2 
      has a highly significant association (P less than 2 X 10(-6] with tumors from 
      patients who subsequently developed a local recurrence of the disease or a distal 
      metastasis.
FAU - Lidereau, R
AU  - Lidereau R
AD  - Centre Rene Huguenin, St. Cloud, France.
FAU - Callahan, R
AU  - Callahan R
FAU - Dickson, C
AU  - Dickson C
FAU - Peters, G
AU  - Peters G
FAU - Escot, C
AU  - Escot C
FAU - Ali, I U
AU  - Ali IU
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Oncogene Res
JT  - Oncogene research
JID - 8801457
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Wnt Proteins)
RN  - 0 (Zebrafish Proteins)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/*genetics/metabolism
MH  - Carcinoma, Intraductal, Noninfiltrating/genetics/metabolism
MH  - Cloning, Molecular
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - Mice
MH  - Proto-Oncogene Proteins/*genetics/isolation & purification
MH  - Proto-Oncogenes
MH  - Wnt Proteins
MH  - *Zebrafish Proteins
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
PST - ppublish
SO  - Oncogene Res. 1988 Feb;2(3):285-91.