PMID- 28357648
OWN - NLM
STAT- MEDLINE
DCOM- 20180131
LR  - 20180131
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 180
IP  - 2
DP  - 2017 Dec
TI  - Ameliorated Effects of (-)-Epigallocatechin Gallate Against Toxicity Induced by 
      Vanadium in the Kidneys of Wistar Rats.
PG  - 239-245
LID - 10.1007/s12011-017-1004-4 [doi]
AB  - The aim of the study was to assess the protective effect of (-)-epigallocatechin 
      gallate (EGCG), a flavonoid abundant in green tea, against ammonium metavanadate 
      (AMV)-induced oxidative stress in male Wistar rats. Four groups of animals have 
      been used, a control group and three test groups. In the first test group, AMV 
      was intra-peritoneally (i.p) injected daily (5 mg/kg body weight for five 
      consecutive days). The second test group of animals was also injected daily with 
      EGCG (5 mg/kg body weight) during the same period. However, the third test group 
      was i.p. injected with both AMV and EGCG (5 mg/kg body weight for five 
      consecutive days). When given alone, AMV induced an oxidative stress evidenced by 
      an increase of lipid peroxidation levels (expressed as TBARS concentration) in 
      kidney. In these animals, activities of superoxide dismutase (SOD), catalase 
      (CAT), and glutathione peroxidase (GPX) were significantly decreased, suggesting 
      significant reduction of the antioxidant defense system at the cell level. Kidney 
      histological sections, showed glomerular hypertrophy and tubular dilatation. In 
      AMV-treated animals receiving EGCG, the oxidative stress was much less pronounced 
      and activities of antioxidant enzymes were kept close to control values. 
      Histopathological changes were less prominent. Our results confirm that green tea 
      and other sources of flavonoids might confer a strong protection against ammonium 
      metavanadate-induced oxidative stress.
FAU - Soussi, Ahlem
AU  - Soussi A
AD  - Laboratory of Animal Ecophysiology, Department of Life Science, Faculty of 
      Science, University of Sfax, PB 802, 3018, Sfax, Tunisia. asoussi2000@yahoo.fr.
FAU - Abdennabi, Raed
AU  - Abdennabi R
AD  - Laboratory of Plant Biotechnology, Faculty of Science, University of Sfax, B.P. 
      1171, 3000, Sfax, Tunisia.
AD  - Laboratory of Pharmacognosy and Natural Products Chemistry, 15771, Athens, 
      Greece.
FAU - Ghorbel, Fatma
AU  - Ghorbel F
AD  - Laboratory of Animal Ecophysiology, Department of Life Science, Faculty of 
      Science, University of Sfax, PB 802, 3018, Sfax, Tunisia.
FAU - Murat, Jean-Claude
AU  - Murat JC
AD  - Laboratory of Cell Biology, Faculty of Medicine, Toulouse, France.
FAU - El Feki, Abdel Fettah
AU  - El Feki AF
AD  - Laboratory of Animal Ecophysiology, Department of Life Science, Faculty of 
      Science, University of Sfax, PB 802, 3018, Sfax, Tunisia.
LA  - eng
PT  - Journal Article
DEP - 20170329
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Antioxidants)
RN  - 0 (Protective Agents)
RN  - 00J9J9XKDE (Vanadium)
RN  - 11103-57-4 (Vitamin A)
RN  - 1406-18-4 (Vitamin E)
RN  - 3WHH0066W5 (Vanadates)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - EC 1.- (Oxidoreductases)
RN  - FL85PX638G (ammonium metavanadate)
SB  - IM
MH  - Acute Kidney Injury/etiology/metabolism/pathology/*prevention & control
MH  - Animals
MH  - Antioxidants/administration & dosage/adverse effects/therapeutic use
MH  - Catechin/administration & dosage/adverse effects/*analogs & 
      derivatives/therapeutic use
MH  - Heavy Metal Poisoning/etiology/*physiopathology
MH  - Hypertrophy
MH  - Injections, Intraperitoneal
MH  - Kidney/*drug effects/metabolism/pathology
MH  - Kidney Glomerulus/drug effects/metabolism/pathology
MH  - Kidney Tubules/drug effects/metabolism/pathology
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Oxidoreductases/antagonists & inhibitors/metabolism
MH  - Protective Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Rats, Wistar
MH  - Vanadates/administration & dosage
MH  - Vanadium/administration & dosage/*poisoning
MH  - Vitamin A/agonists/antagonists & inhibitors/blood
MH  - Vitamin E/agonists/antagonists & inhibitors/blood
OTO - NOTNLM
OT  - Catechin
OT  - Green tea
OT  - Metavanadate
OT  - Oxidative stress
OT  - Vitamins E and A
EDAT- 2017/03/31 06:00
MHDA- 2018/02/01 06:00
CRDT- 2017/03/31 06:00
PHST- 2017/02/09 00:00 [received]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/03/31 06:00 [pubmed]
PHST- 2018/02/01 06:00 [medline]
PHST- 2017/03/31 06:00 [entrez]
AID - 10.1007/s12011-017-1004-4 [pii]
AID - 10.1007/s12011-017-1004-4 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2017 Dec;180(2):239-245. doi: 10.1007/s12011-017-1004-4. 
      Epub 2017 Mar 29.