PMID- 28359223
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20180503
IS  - 1793-6462 (Electronic)
IS  - 0129-0657 (Linking)
VI  - 27
IP  - 7
DP  - 2017 Nov
TI  - Epileptic Discharge Related Functional Connectivity Within and Between Networks 
      in Benign Epilepsy with Centrotemporal Spikes.
PG  - 1750018
LID - 10.1142/S0129065717500186 [doi]
AB  - Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy 
      syndrome associated with abnormalities in neurocognitive domains, particularly 
      during interictal epileptiform discharges (IEDs). Here, we investigated the 
      effects of IEDs on brain's intrinsic connectivity networks in 43 BECTS patients 
      and 28 matched healthy controls (HCs). Patients were further divided into IED and 
      non-IED subgroups based on simultaneous EEG-fMRI recordings. Functional 
      connectivity within and between five networks, corresponding to seizure 
      origination and cognitive processes, were analyzed to measure IED effects. We 
      found that patients exhibited increased connectivity within the auditory network 
      (AN) and the somato-motor network (SMN), and decreased connectivity within the 
      basal ganglia network and the dorsal attention network, suggesting that both 
      transient and chronic seizure activity may disturb normal network organization. 
      The IED group showed decreased functional connectivity within the default mode 
      network (DMN) compared with the non-IED group and HCs, implying that the DMN was 
      selectively impaired during epileptiform discharges associated with altered 
      self-referential cognitive functions. Moreover, the IED group exhibited increased 
      positive correlations between the AN and the SMN, which suggests a possible 
      excessive influence of centrotemporal spiking on information processing in the 
      auditory system. The association between epileptic activity and network 
      dysfunctions highlights their importance in investigating the pathological 
      mechanism underlying BECTS.
FAU - Li, Rong
AU  - Li R
AD  - * Key Laboratory for Neuroinformation of Ministry of Education, Center for 
      Information in BioMedicine, School of Life Science and Technology, University of 
      Electronic Science and Technology of China, Chengdu 610054, P. R. China.
FAU - Ji, Gong-Jun
AU  - Ji GJ
AD  - dagger Laboratory of Cognitive Neuropsychology, Department of Medical Psychology, 
      Anhui Medical University, Hefei 230000, P. R. China.
FAU - Yu, Yangyang
AU  - Yu Y
AD  - * Key Laboratory for Neuroinformation of Ministry of Education, Center for 
      Information in BioMedicine, School of Life Science and Technology, University of 
      Electronic Science and Technology of China, Chengdu 610054, P. R. China.
FAU - Yu, Yang
AU  - Yu Y
AD  - double dagger Department of Psychiatry, the Second Affiliated Hospital of Medial College, 
      Zhejiang University, Zhejiang 310009, P. R. China.
FAU - Ding, Mei-Ping
AU  - Ding MP
AD  -  section sign Department of Neurology, the Second Affiliated Hospital of Medial College, 
      Zhejiang University, Zhejiang 310009, P. R. China.
FAU - Tang, Ye-Lei
AU  - Tang YL
AD  -  section sign Department of Neurology, the Second Affiliated Hospital of Medial College, 
      Zhejiang University, Zhejiang 310009, P. R. China.
FAU - Chen, Huafu
AU  - Chen H
AD  - * Key Laboratory for Neuroinformation of Ministry of Education, Center for 
      Information in BioMedicine, School of Life Science and Technology, University of 
      Electronic Science and Technology of China, Chengdu 610054, P. R. China.
FAU - Liao, Wei
AU  - Liao W
AD  - * Key Laboratory for Neuroinformation of Ministry of Education, Center for 
      Information in BioMedicine, School of Life Science and Technology, University of 
      Electronic Science and Technology of China, Chengdu 610054, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20170110
PL  - Singapore
TA  - Int J Neural Syst
JT  - International journal of neural systems
JID - 9100527
RN  - 0 (Anticonvulsants)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adolescent
MH  - Anticonvulsants/therapeutic use
MH  - Brain/*physiopathology
MH  - *Brain Mapping
MH  - Brain Waves/*physiology
MH  - Case-Control Studies
MH  - Child
MH  - Computer Simulation
MH  - Electroencephalography
MH  - Epilepsy, Rolandic/diagnostic imaging/drug therapy/*pathology/*physiopathology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Models, Neurological
MH  - Neural Pathways/diagnostic imaging/*physiopathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Benign epilepsy with centrotemporal spikes
OT  - EEG-fMRI
OT  - independent component analysis
OT  - interictal epileptiform discharges
OT  - intrinsic connectivity networks
EDAT- 2017/04/01 06:00
MHDA- 2018/05/04 06:00
CRDT- 2017/04/01 06:00
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
AID - 10.1142/S0129065717500186 [doi]
PST - ppublish
SO  - Int J Neural Syst. 2017 Nov;27(7):1750018. doi: 10.1142/S0129065717500186. Epub 
      2017 Jan 10.