PMID- 28359782
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20181113
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 180
DP  - 2017 Jul
TI  - In vivo IL-4 prevents allo-antigen driven CD8(+) CTL development.
PG  - 11-24
LID - S1521-6616(17)30100-6 [pii]
LID - 10.1016/j.clim.2017.03.008 [doi]
AB  - IL-4 has been shown to suppress acute graft vs. host disease (GVHD) in irradiated 
      hosts. Here we evaluated whether IL-4 suppresses acute GVHD in the un-irradiated 
      parent-into-F1 GVHD model with relevance to renal allograft rejection. IL-4 
      completely suppressed CD8 CTL when administered with donor cells however this 
      effect was lost if its administration was delayed 3days. IL-4 did not inhibit 
      donor CD8(+) T cell homing to the host spleen but rather prevented donor CD8(+) T 
      cell differentiation into CTLs. Studies with IL-4Ralpha-deficient donor cells or 
      recipient mice demonstrated that IL-4 effects on the host, rather than, or in 
      addition to IL-4 effects on donor cells, were critical for suppression of CTL. 
      Because IL-4 decreased all splenic dendritic cell populations and increased 
      neutrophil and CD8(+) T cells, IL-4 may suppress donor CD8(+) CTL by decreasing 
      Ag presentation and/or increasing host myeloid and CD8(+) T cell suppression of 
      donor T cells.
CI  - Published by Elsevier Inc.
FAU - Via, Charles S
AU  - Via CS
AD  - Department of Pathology, Uniformed Services University of Health Sciences, 
      Bethesda, MD 20814, United States. Electronic address: charles.via@usuhs.edu.
FAU - Soloviova, Kateryna
AU  - Soloviova K
AD  - Department of Pathology, Uniformed Services University of Health Sciences, 
      Bethesda, MD 20814, United States.
FAU - Puliaiev, Maksym
AU  - Puliaiev M
AD  - Department of Pathology, Uniformed Services University of Health Sciences, 
      Bethesda, MD 20814, United States.
FAU - Puliav, Roman
AU  - Puliav R
AD  - Department of Pathology, Uniformed Services University of Health Sciences, 
      Bethesda, MD 20814, United States.
FAU - Puliaeva, Irina
AU  - Puliaeva I
AD  - Department of Pathology, Uniformed Services University of Health Sciences, 
      Bethesda, MD 20814, United States.
FAU - Morris, Suzanne C
AU  - Morris SC
AD  - Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, 
      OH 45267, United States; Division of Immunobiology, Cincinnati Children's 
      Hospital Medical Center, Cincinnati, OH 45229, United States; Department of 
      Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, 
      United States.
FAU - Finkelman, Fred D
AU  - Finkelman FD
AD  - Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, 
      OH 45267, United States; Division of Immunobiology, Cincinnati Children's 
      Hospital Medical Center, Cincinnati, OH 45229, United States; Department of 
      Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, 
      United States.
LA  - eng
GR  - R01 AI047466/AI/NIAID NIH HHS/United States
GR  - R01 AI070300/AI/NIAID NIH HHS/United States
GR  - R56 AI047466/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170327
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Isoantigens)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/immunology
MH  - CD4-Positive T-Lymphocytes/immunology/transplantation
MH  - CD8-Positive T-Lymphocytes/*immunology/transplantation
MH  - Graft vs Host Disease/*immunology/therapy
MH  - Interleukin-4/*immunology
MH  - Isoantigens/*immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
PMC - PMC5484589
MID - NIHMS866241
OTO - NOTNLM
OT  - CTL
OT  - Cytokine
OT  - Graft-vs.-host disease
OT  - IL-4
OT  - Mouse
OT  - T cells
EDAT- 2017/04/01 06:00
MHDA- 2017/08/30 06:00
PMCR- 2018/07/01
CRDT- 2017/04/01 06:00
PHST- 2017/02/08 00:00 [received]
PHST- 2017/03/17 00:00 [revised]
PHST- 2017/03/18 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
PHST- 2018/07/01 00:00 [pmc-release]
AID - S1521-6616(17)30100-6 [pii]
AID - 10.1016/j.clim.2017.03.008 [doi]
PST - ppublish
SO  - Clin Immunol. 2017 Jul;180:11-24. doi: 10.1016/j.clim.2017.03.008. Epub 2017 Mar 
      27.