PMID- 28359802
OWN - NLM
STAT- MEDLINE
DCOM- 20170704
LR  - 20200225
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 273
DP  - 2017 May 5
TI  - Low level arsenite exposures suppress the development of bone marrow erythroid 
      progenitors and result in anemia in adult male mice.
PG  - 106-111
LID - S0378-4274(17)30123-6 [pii]
LID - 10.1016/j.toxlet.2017.03.021 [doi]
AB  - Epidemiological studies report an association between chronic arsenic (As) 
      exposure and anemia in men, and women who are predisposed to anemia. The purpose 
      of these studies was to determine whether a 60 d drinking water exposure of adult 
      male C57BL/6J mice to 0, 100, and 500ppb arsenite (As(+3)) results in anemia due 
      to alterations in erythroid progenitor cell development in the bone marrow. 
      Exposure to 500ppb As(+3) for 60 d resulted in a reduction of mean corpuscular 
      hemoglobin (MCH) levels, but did not significantly alter red blood cell (RBC) 
      counts, hemoglobin (Hgb) levels, mean corpuscular Hgb concentrations (MCHC), or 
      mean corpuscular volumes (MCV). Attenuation of burst-forming unit-erythroid 
      (BFU-E) colony formation was observed in bone marrow cells of mice exposed to 
      500ppb As(+3). The differentiation of late-stage bone marrow erythroblasts as 
      defined by CD71 and Ter119 surface marker expression was reduced with the 500ppb 
      As(+3) exposure. Mice exposed to 500ppb As(+3) also had elevated serum levels of 
      erythropoietin (EPO). Collectively, these results show that exposure to low 
      levels of As(+3) attenuate the development of early BFU-E cells and reduce the 
      differentiation of late-stage erythroblasts. This suppression of bone marrow 
      erythropoiesis may be a contributing factor to the mild hypochromic anemia 
      observed in 500ppb As(+3) exposed mice.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Medina, Sebastian
AU  - Medina S
AD  - The University of New Mexico College of Pharmacy, Department of Pharmaceutical 
      Sciences, Albuquerque, NM 87131, United States.
FAU - Xu, Huan
AU  - Xu H
AD  - The University of New Mexico College of Pharmacy, Department of Pharmaceutical 
      Sciences, Albuquerque, NM 87131, United States.
FAU - Wang, Shu Chun
AU  - Wang SC
AD  - Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Tianjin, 300020, China.
FAU - Lauer, Fredine T
AU  - Lauer FT
AD  - The University of New Mexico College of Pharmacy, Department of Pharmaceutical 
      Sciences, Albuquerque, NM 87131, United States.
FAU - Liu, Ke Jian
AU  - Liu KJ
AD  - The University of New Mexico College of Pharmacy, Department of Pharmaceutical 
      Sciences, Albuquerque, NM 87131, United States.
FAU - Burchiel, Scott W
AU  - Burchiel SW
AD  - The University of New Mexico College of Pharmacy, Department of Pharmaceutical 
      Sciences, Albuquerque, NM 87131, United States. Electronic address: 
      sburchiel@salud.unm.edu.
LA  - eng
GR  - R01 ES019968/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20170327
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Arsenites)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hemoglobins)
RN  - 11096-26-7 (Erythropoietin)
RN  - N5509X556J (arsenite)
SB  - IM
MH  - Anemia/blood/*chemically induced/pathology
MH  - Animals
MH  - Arsenites/*toxicity
MH  - Bone Marrow Cells/cytology/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drinking
MH  - Environmental Pollutants/*toxicity
MH  - Erythroid Precursor Cells/cytology/*drug effects
MH  - Erythropoiesis/*drug effects
MH  - Erythropoietin/blood
MH  - Hemoglobins/analysis
MH  - Male
MH  - Mice, Inbred C57BL
PMC - PMC6598710
MID - NIHMS1532680
OTO - NOTNLM
OT  - Anemia
OT  - Arsenite
OT  - Bone marrow
OT  - Erythroid progenitor cells
OT  - Erythropoiesis
EDAT- 2017/04/01 06:00
MHDA- 2017/07/05 06:00
PMCR- 2019/06/28
CRDT- 2017/04/01 06:00
PHST- 2017/02/04 00:00 [received]
PHST- 2017/03/15 00:00 [revised]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2017/07/05 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
PHST- 2019/06/28 00:00 [pmc-release]
AID - S0378-4274(17)30123-6 [pii]
AID - 10.1016/j.toxlet.2017.03.021 [doi]
PST - ppublish
SO  - Toxicol Lett. 2017 May 5;273:106-111. doi: 10.1016/j.toxlet.2017.03.021. Epub 
      2017 Mar 27.