PMID- 28359883
OWN - NLM
STAT- MEDLINE
DCOM- 20180207
LR  - 20181113
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 328
DP  - 2017 Jun 15
TI  - The BDNF Val(66)Met polymorphism is associated with structural neuroanatomical 
      differences in young children.
PG  - 48-56
LID - S0166-4328(16)30644-1 [pii]
LID - 10.1016/j.bbr.2017.03.014 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) Val(66)Met single nucleotide 
      polymorphism (SNP) has been associated with individual differences in brain 
      structure and function, and cognition. Research on BDNF's influence on brain and 
      cognition has largely been limited to adults, and little is known about the 
      association of this gene, and specifically the Val(66)Met polymorphism, with 
      developing brain structure and emerging cognitive functions in children. We 
      performed a targeted genetic association analysis on cortical thickness, surface 
      area, and subcortical volume in 78 children (ages 6-10) who were Val homozygotes 
      (homozygous Val/Val carriers) or Met carriers (Val/Met, Met/Met) for the 
      Val(66)Met locus using Atlas-based brain segmentation. We observed greater 
      cortical thickness for Val homozygotes in regions supporting declarative memory 
      systems (anterior temporal pole/entorhinal cortex), consistent with adult 
      findings. Met carriers had greater surface area in the prefrontal and parietal 
      cortices and greater cortical thickness in lateral occipital/parietal cortex in 
      contrast to prior adult findings that may relate to performance on cognitive 
      tasks supported by these regions in Met carriers. Finally, we found larger right 
      hippocampal volume in Met carriers, although inconsistent with adult findings 
      (generally reports larger volumes for Val homozygotes), is consistent with a 
      recent finding in children. Gene expression levels vary across different brain 
      regions and across development and our findings highlight the need to consider 
      this developmental change in explorations of BDNF-brain relationships. The impact 
      of the BDNF Val(66)Met polymorphism on the structure of the developing brain 
      therefore reflects regionally-specific developmental changes in BDNF expression 
      and cortical maturation trajectories.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Jasinska, Kaja K
AU  - Jasinska KK
AD  - University of Delaware, Newark, DE, USA; Haskins Laboratories, New Haven, CT, 
      USA. Electronic address: jasinska@udel.edu.
FAU - Molfese, Peter J
AU  - Molfese PJ
AD  - Haskins Laboratories, New Haven, CT, USA; University of Connecticut, Storrs, CT, 
      USA.
FAU - Kornilov, Sergey A
AU  - Kornilov SA
AD  - Haskins Laboratories, New Haven, CT, USA; University of Houston, Houston, TX, 
      USA; Baylor College of Medicine, Houston, TX, USA; Moscow State University, 
      Moscow, Russian Federation; Saint-Petersburg State University, Saint-Petersburg, 
      Russian Federation.
FAU - Mencl, W Einar
AU  - Mencl WE
AD  - Haskins Laboratories, New Haven, CT, USA; Yale University, New Haven, CT, USA.
FAU - Frost, Stephen J
AU  - Frost SJ
AD  - Haskins Laboratories, New Haven, CT, USA.
FAU - Lee, Maria
AU  - Lee M
AD  - Yale University, New Haven, CT, USA.
FAU - Pugh, Kenneth R
AU  - Pugh KR
AD  - Haskins Laboratories, New Haven, CT, USA; University of Connecticut, Storrs, CT, 
      USA; Yale University, New Haven, CT, USA.
FAU - Grigorenko, Elena L
AU  - Grigorenko EL
AD  - Haskins Laboratories, New Haven, CT, USA; Yale University, New Haven, CT, USA; 
      University of Houston, Houston, TX, USA; Baylor College of Medicine, Houston, TX, 
      USA; Moscow State University, Moscow, Russian Federation; Saint-Petersburg State 
      University, Saint-Petersburg, Russian Federation; Moscow State University for 
      Psychology and Education, Moscow, Russian Federation.
FAU - Landi, Nicole
AU  - Landi N
AD  - Haskins Laboratories, New Haven, CT, USA; University of Connecticut, Storrs, CT, 
      USA; Yale University, New Haven, CT, USA.
LA  - eng
GR  - R01 HD065794/HD/NICHD NIH HHS/United States
GR  - R03 HD053409/HD/NICHD NIH HHS/United States
GR  - P20 HD091013/HD/NICHD NIH HHS/United States
GR  - R21 DA030665/DA/NIDA NIH HHS/United States
GR  - P50 HD052120/HD/NICHD NIH HHS/United States
GR  - R01 HD040411/HD/NICHD NIH HHS/United States
GR  - R01 HD048830/HD/NICHD NIH HHS/United States
GR  - P01 HD001994/HD/NICHD NIH HHS/United States
GR  - R01 HD086168/HD/NICHD NIH HHS/United States
PT  - Journal Article
DEP - 20170327
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebral Cortex/*diagnostic imaging
MH  - Child
MH  - Female
MH  - Genetic Association Studies
MH  - Heterozygote
MH  - Hippocampus/*diagnostic imaging
MH  - Humans
MH  - Intelligence
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Organ Size
MH  - *Polymorphism, Single Nucleotide
PMC - PMC5536104
MID - NIHMS867805
OTO - NOTNLM
OT  - BDNF
OT  - Cortical thickness
OT  - Development
OT  - Gray matter volume
OT  - Neurogenetics
OT  - Surface area
OT  - rs6265
OT  - sMRI neuroimaging
EDAT- 2017/04/01 06:00
MHDA- 2018/02/08 06:00
PMCR- 2018/06/15
CRDT- 2017/04/01 06:00
PHST- 2016/09/18 00:00 [received]
PHST- 2017/02/05 00:00 [revised]
PHST- 2017/03/07 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2018/02/08 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
PHST- 2018/06/15 00:00 [pmc-release]
AID - S0166-4328(16)30644-1 [pii]
AID - 10.1016/j.bbr.2017.03.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 Jun 15;328:48-56. doi: 10.1016/j.bbr.2017.03.014. Epub 2017 
      Mar 27.