PMID- 28359918
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20220311
IS  - 2299-5684 (Electronic)
IS  - 1734-1140 (Linking)
VI  - 69
IP  - 3
DP  - 2017 Jun
TI  - The effects of desipramine, fluoxetine, or tianeptine on changes in bulbar BDNF 
      levels induced by chronic social instability stress and inflammation.
PG  - 520-525
LID - S1734-1140(16)30134-7 [pii]
LID - 10.1016/j.pharep.2017.01.004 [doi]
AB  - BACKGROUND: Stress is a major predisposing factor in the development of 
      psychiatric disorders and potential source of augmented inflammatory processes in 
      the brain. Increasing body of evidence shows an important role of alterations in 
      the olfactory bulbs (OBs) function in stress-related disorders. The aim of the 
      present study was to investigate the impact of antidepressants on the alterations 
      of brain-derived neurotrophic factor (BDNF) induced by lipopolysaccharide (LPS) 
      in female rats subjected to chronic social instability stress (CSIS). METHODS: 9 
      weeks old female rats were subjected to CSIS and injected ip once daily with 
      desipramine (10mg/kg), fluoxetine (5mg/kg), or tianeptine (10mg/kg) for 4 weeks. 
      On the last day of the experiment, rats being at the estrus phase of cycle were 
      injected ip with LPS (1mg/kg) or saline. RESULTS: The BDNF mRNA and protein 
      levels were evaluated in the olfactory bulbs. and the BDNF protein levels were 
      measured in plasma. A single LPS administration in the stressed rats resulted in 
      significant decrease in the bulbar BDNF mRNA, but not in the protein level. 
      Chronic administration of desipramine, fluoxetine, or tianeptine increased the 
      BDNF mRNA expression and protein levels in the LPS-injected stressed rats. There 
      was no effect of the studied antidepressants on the reduction of the plasma BDNF 
      protein level induced by CSIS and LPS. CONCLUSIONS: These results suggest that 
      studied antidepressants were effective in inhibiting the impact of LPS on BDNF 
      expression in the stressed rats what may be significant for beneficial action of 
      this drugs.
CI  - Copyright (c) 2017 Institute of Pharmacology, Polish Academy of Sciences. Published 
      by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
FAU - Nowacka-Chmielewska, Marta M
AU  - Nowacka-Chmielewska MM
AD  - Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka 
      Academy of Physical Education, Katowice, Poland; Department of Pharmacology, 
      School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland. 
      Electronic address: m.nowacka@awf.katowice.pl.
FAU - Kasprowska, Daniela
AU  - Kasprowska D
AD  - Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka 
      Academy of Physical Education, Katowice, Poland.
FAU - Paul-Samojedny, Monika
AU  - Paul-Samojedny M
AD  - Department of Medical Genetics, School of Pharmacy with the Division of 
      Laboratory Medicine, Medical University of Silesia, Sosnowiec, Poland.
FAU - Bielecka-Wajdman, Anna M
AU  - Bielecka-Wajdman AM
AD  - Department of Pharmacology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
FAU - Barski, Jaroslaw J
AU  - Barski JJ
AD  - Department of Physiology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland; Center for Experimental Medicine, School of Medicine 
      in Katowice, Medical University of Silesia, Katowice, Poland.
FAU - Malecki, Andrzej
AU  - Malecki A
AD  - Laboratory of Molecular Biology, Faculty of Physiotherapy, The Jerzy Kukuczka 
      Academy of Physical Education, Katowice, Poland.
FAU - Obuchowicz, Ewa
AU  - Obuchowicz E
AD  - Department of Pharmacology, School of Medicine in Katowice, Medical University of 
      Silesia, Katowice, Poland.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170117
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Thiazepines)
RN  - 01K63SUP8D (Fluoxetine)
RN  - 0T493YFU8O (tianeptine)
RN  - TG537D343B (Desipramine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Desipramine/*pharmacology
MH  - Disease Models, Animal
MH  - Female
MH  - Fluoxetine/*pharmacology
MH  - Inflammation/drug therapy/pathology
MH  - Lipopolysaccharides/pharmacology
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*drug therapy/physiopathology
MH  - Thiazepines/*pharmacology
OTO - NOTNLM
OT  - Antidepressants
OT  - BDNF
OT  - Chronic social stress
OT  - LPS
OT  - Olfactory bulbs
EDAT- 2017/04/01 06:00
MHDA- 2017/11/08 06:00
CRDT- 2017/04/01 06:00
PHST- 2016/09/12 00:00 [received]
PHST- 2017/01/09 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
AID - S1734-1140(16)30134-7 [pii]
AID - 10.1016/j.pharep.2017.01.004 [doi]
PST - ppublish
SO  - Pharmacol Rep. 2017 Jun;69(3):520-525. doi: 10.1016/j.pharep.2017.01.004. Epub 
      2017 Jan 17.