PMID- 28360512
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 1177-889X (Print)
IS  - 1177-889X (Electronic)
IS  - 1177-889X (Linking)
VI  - 11
DP  - 2017
TI  - Treatment adherence in patients with type 2 diabetes mellitus correlates with 
      different coping styles, low perception of self-influence on disease, and 
      depressive symptoms.
PG  - 587-595
LID - 10.2147/PPA.S124605 [doi]
AB  - BACKGROUND: Insulin analogs are regarded as more convenient to use than human 
      insulin; however, they require a different administration scheme due to their 
      unique pharmacokinetic and pharmacodynamic properties. This study aimed to assess 
      difficulties with adherence to treatment with insulin analogs in patients with 
      type 2 diabetes mellitus (T2DM), who had previously been treated with human 
      insulin. The associations between difficulties with adherence and clinical, 
      demographic, and psychological characteristics were also evaluated. PATIENTS AND 
      METHODS: The study was conducted on 3,467 consecutively enrolled patients with 
      T2DM (54.4% women), mean age 63.9 years (SD =9.57), who had recently undergone a 
      physician-directed change in treatment from human insulin to insulin analogs. The 
      questionnaires addressed difficulties with switching the therapy, coping styles, 
      well-being, and perception of self-influence on the disease. RESULTS: No 
      adherence problems in switching therapy were reported in 56.6% of patients. 
      Specific moderate difficulties were reported in 10.4%-22.1% of patients, major 
      difficulties in 0.7%-6.9% of patients, and very significant difficulties in 
      0.03%-1.3% of patients. Overall, remembering to modify the insulin dose in the 
      case of additional meals was the most frequently reported difficulty, and 
      problems with identifying hypoglycemic symptoms were the least frequently 
      reported. The increased risk of difficulties was moderately related to low 
      perception of self-influence on diabetes and poor well-being. The intensity of 
      problems was higher among those who were less-educated, lived in rural areas, had 
      complications, and/or reported maladaptive coping styles. CONCLUSION: Switching 
      from human insulin to an insulin analog did not cause adherence problems in more 
      than half of the patients. In the remaining patients, difficulties in adherence 
      correlated with maladaptive coping styles, low perception of self-influence on 
      disease course, and depressive symptoms.
FAU - Kokoszka, Andrzej
AU  - Kokoszka A
AD  - II Department of Psychiatry, Medical University of Warsaw; Department of 
      Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170317
PL  - New Zealand
TA  - Patient Prefer Adherence
JT  - Patient preference and adherence
JID - 101475748
PMC - PMC5364005
OTO - NOTNLM
OT  - adherence
OT  - insulin
OT  - insulin analogs
OT  - treatment adherence
OT  - type 2 diabetes mellitus
EDAT- 2017/04/01 06:00
MHDA- 2017/04/01 06:01
PMCR- 2017/03/17
CRDT- 2017/04/01 06:00
PHST- 2017/04/01 06:00 [entrez]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2017/04/01 06:01 [medline]
PHST- 2017/03/17 00:00 [pmc-release]
AID - ppa-11-587 [pii]
AID - 10.2147/PPA.S124605 [doi]
PST - epublish
SO  - Patient Prefer Adherence. 2017 Mar 17;11:587-595. doi: 10.2147/PPA.S124605. 
      eCollection 2017.