PMID- 28361262
OWN - NLM
STAT- MEDLINE
DCOM- 20180302
LR  - 20210109
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 32
IP  - 3
DP  - 2017 Jun
TI  - The interrelationship of metabolic syndrome and neurodegenerative diseases with 
      focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone.
PG  - 651-665
LID - 10.1007/s11011-017-9997-0 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome 
      (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, 
      Huntington's disease, Parkinson's disease and depression. If one factor plays an 
      essential role in the pathogenesis of two diseases, it can be concluded that 
      there might be a common root in these two diseases, as well. This review was 
      aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD 
      and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy 
      and BDFN administration, in controlling MetS and NDD.
FAU - Motamedi, Shima
AU  - Motamedi S
AD  - Graduate of Doctor of Veterinary Medicine, Faculty of Veterinary Medicine, Razi 
      University, Kermanshah, Iran.
FAU - Karimi, Isaac
AU  - Karimi I
AUID- ORCID: 0000-0001-7415-0472
AD  - Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. 
      karimiisaac@razi.ac.ir.
FAU - Jafari, Fariba
AU  - Jafari F
AD  - Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad 
      University, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170330
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cardiovascular Diseases/epidemiology/metabolism/psychology
MH  - Humans
MH  - Mental Disorders/epidemiology/metabolism/psychology
MH  - Metabolic Syndrome/*epidemiology/*metabolism/psychology
MH  - Neurodegenerative Diseases/*epidemiology/*metabolism/psychology
MH  - Obesity/epidemiology/metabolism/psychology
OTO - NOTNLM
OT  - BDNF
OT  - Depression
OT  - Metabolic syndrome
OT  - Neurodegenerative diseases
OT  - Obesity
EDAT- 2017/04/01 06:00
MHDA- 2018/03/03 06:00
CRDT- 2017/04/01 06:00
PHST- 2016/12/19 00:00 [received]
PHST- 2017/03/20 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2018/03/03 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
AID - 10.1007/s11011-017-9997-0 [pii]
AID - 10.1007/s11011-017-9997-0 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2017 Jun;32(3):651-665. doi: 10.1007/s11011-017-9997-0. Epub 
      2017 Mar 30.