PMID- 28361746
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20180618
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 17
DP  - 2017 Feb
TI  - Short-term effects of Mediterranean-type diet intervention on soluble cellular 
      adhesion molecules in subjects with abdominal obesity.
PG  - 38-43
LID - S2405-4577(16)30340-0 [pii]
LID - 10.1016/j.clnesp.2016.11.002 [doi]
AB  - BACKGROUND & AIMS: Abdominal obesity (AO) is associated with increased risk for 
      cardiovascular disease and with increased production of adhesion molecules. The 
      present work examined the effect of a Mediterranean-style diet on soluble 
      cellular adhesion molecules in individuals with AO. METHODS: Ninety subjects with 
      AO without cardiovascular disease or diabetes mellitus were randomly allocated to 
      the intervention or control group and were instructed to follow a 
      Mediterranean-style diet for two months. Intervention group followed a specific 
      relevant food plan with close dietetic supervision and provision of basic foods. 
      Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell 
      adhesion molecule-1 (sVCAM-1), sP and sE-selectin, C-reactive protein (CRP) and 
      interleukin-6 (IL-6) were measured. RESULTS: Subjects in the intervention group 
      increased their intake of total fat, monounsaturated fatty acids, dietary fiber, 
      vitamin C, and alcohol compared to controls, while decreased their intake of 
      saturated fat. Although there was a significant decrease in CRP, sP-selectin and 
      in sE-selectin in the intervention group, and an increase in sVCAM-1 in the 
      control group, between-group analysis showed no statistically significant 
      differences. There were also no significant changes in sICAM-1, and IL-6 levels 
      after intervention. CONCLUSIONS: Mediterranean-type diet for two months combined 
      with close dietetic supervision showed a beneficial tendency towards the 
      down-regulation of some markers of vascular inflammation, although the comparison 
      between groups after the intervention did not reach statistical significance. A 
      longer period of dietary intervention may be required to further support these 
      changes.
CI  - Copyright (c) 2016. Published by Elsevier Ltd.
FAU - Rallidis, Loukianos S
AU  - Rallidis LS
AD  - Second Department of Cardiology, Attikon Hospital, School of Medicine, University 
      of Athens, Greece.
FAU - Kolomvotsou, Anastasia
AU  - Kolomvotsou A
AD  - Unit of Human Nutrition, Department of Food Science and Human Nutrition, 
      Agricultural University of Athens, Greece.
FAU - Lekakis, John
AU  - Lekakis J
AD  - Second Department of Cardiology, Attikon Hospital, School of Medicine, University 
      of Athens, Greece.
FAU - Farajian, Paul
AU  - Farajian P
AD  - Unit of Human Nutrition, Department of Food Science and Human Nutrition, 
      Agricultural University of Athens, Greece.
FAU - Vamvakou, Georgia
AU  - Vamvakou G
AD  - Second Department of Cardiology, Attikon Hospital, School of Medicine, University 
      of Athens, Greece.
FAU - Dagres, Nikolaos
AU  - Dagres N
AD  - Second Department of Cardiology, Attikon Hospital, School of Medicine, University 
      of Athens, Greece.
FAU - Zolindaki, Maria
AU  - Zolindaki M
AD  - Biochemistry Laboratory, General Hospital of Nikea, Piraeus, Greece.
FAU - Efstathiou, Stamatis
AU  - Efstathiou S
AD  - Hygeias Melathron Infirmary, Athens, Greece.
FAU - Anastasiou-Nana, Maria
AU  - Anastasiou-Nana M
AD  - Second Department of Cardiology, Attikon Hospital, School of Medicine, University 
      of Athens, Greece.
FAU - Zampelas, Antonis
AU  - Zampelas A
AD  - Unit of Human Nutrition, Department of Food Science and Human Nutrition, 
      Agricultural University of Athens, Greece. Electronic address: azampelas@aua.gr.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161223
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cell Adhesion Molecules/*blood
MH  - *Diet, Mediterranean
MH  - Down-Regulation
MH  - Female
MH  - Greece
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - Obesity, Abdominal/blood/diagnosis/*diet therapy/physiopathology
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Cellular adhesion molecules
OT  - Intervention
OT  - Mediterranean diet
EDAT- 2017/04/01 06:00
MHDA- 2018/06/19 06:00
CRDT- 2017/04/01 06:00
PHST- 2015/09/21 00:00 [received]
PHST- 2016/07/25 00:00 [revised]
PHST- 2016/11/28 00:00 [accepted]
PHST- 2017/04/01 06:00 [entrez]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
AID - S2405-4577(16)30340-0 [pii]
AID - 10.1016/j.clnesp.2016.11.002 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2017 Feb;17:38-43. doi: 10.1016/j.clnesp.2016.11.002. Epub 2016 
      Dec 23.