PMID- 28362999
OWN - NLM
STAT- MEDLINE
DCOM- 20170503
LR  - 20170503
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Mar 30
TI  - Effects of ginsenoside Rg1 on glucose metabolism and liver injury in 
      streptozotocin-induced type 2 diabetic rats.
LID - 10.4238/gmr16019463 [doi]
AB  - Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by 
      high blood glucose levels. T2-DM patients suffer from many complications, such as 
      diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ 
      involved in both glucose and lipid metabolism, is primarily damaged in T2-DM 
      patients, especially in those with high levels of blood lipid. In this study, the 
      hepatoprotective activity of ginsenoside Rg1 was investigated in a T2-DM rat 
      model. The results revealed a potent hepatoprotective effect of ginsenoside Rg1. 
      This effect was primarily mediated by the antiapoptotic effect, inhibition of JNK 
      activity, and suppression of inflammation after ginsenoside Rg1 treatment. 
      Ginsenoside Rg1 also lowered the blood glucose level and insulin resistance index 
      in T2-DM rats. Moreover, the blood lipid profile (total cholesterol, 
      triglycerides, and low-density lipoprotein cholesterol levels) and liver function 
      (aspartate transaminase and alanine transaminase levels) improved after 
      ginsenoside Rg1 treatment. The aforementioned hepatoprotective effects of 
      ginsenoside Rg1 in the T2-DM rat model suggests its clinical potential as an 
      adjuvant drug for T2-DM therapy, especially for T2-DM patients with fatty liver 
      disease.
FAU - Tian, W
AU  - Tian W
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
FAU - Chen, L
AU  - Chen L
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
AD  - Department of Biomedical Science, School of Medicine, Kunming University of 
      Science and Technology, Kunming, Yunnan, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
FAU - Wang, B
AU  - Wang B
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
FAU - Li, X B
AU  - Li XB
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
FAU - Fan, K R
AU  - Fan KR
AD  - School of Life Science and Technology, Southwest Jiaotong University, Chongqing, 
      China.
FAU - Ai, C H
AU  - Ai CH
AD  - Department of Basic Medicine, Yunnan University of Traditional Chinese Medicine, 
      Kunming, Yunnan, China.
FAU - Xia, X
AU  - Xia X
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China.
FAU - Li, S D
AU  - Li SD
AD  - Department of Basic Medicine, Kunming Medical University, Kunming, Yunnan, China 
      liyanken@126.com.
FAU - Li, Y
AU  - Li Y
AD  - Department of Cadre Health, First People's Hospital of Yunnan Province, Kunming, 
      Yunnan, China liyanken@126.com.
LA  - eng
PT  - Journal Article
DEP - 20170330
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Blood Glucose)
RN  - 0 (Ginsenosides)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - IY9XDZ35W2 (Glucose)
RN  - PJ788634QY (ginsenoside Rg1)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/blood/drug therapy/metabolism
MH  - Ginsenosides/*pharmacology
MH  - Glucose/metabolism
MH  - Insulin/blood
MH  - JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
MH  - Lipids/blood
MH  - Liver/*drug effects/metabolism/pathology
MH  - Liver Diseases/blood/*drug therapy/*metabolism/pathology
MH  - Male
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2017/04/01 06:00
MHDA- 2017/05/04 06:00
CRDT- 2017/04/01 06:00
PHST- 2017/04/01 06:00 [entrez]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2017/05/04 06:00 [medline]
AID - gmr-16-01-gmr.16019463 [pii]
AID - 10.4238/gmr16019463 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 Mar 30;16(1). doi: 10.4238/gmr16019463.