PMID- 28363108
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20180326
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 47
DP  - 2017 Jun
TI  - A novel small molecule compound possesses immunomodulatory properties on bone 
      marrow-derived dendritic cells via TLR7 signaling pathway and alleviates the 
      development of SLE.
PG  - 47-52
LID - S1567-5769(17)30120-0 [pii]
LID - 10.1016/j.intimp.2017.03.023 [doi]
AB  - Dendritic cells (DCs) play an important role in the development and maintenance 
      of immune tolerance. Activation of TLR7, which is expressed in DCs, is thought to 
      contribute to the complex pathophysiology of systemic lupus erythematosus (SLE). 
      In this study, we analyzed the in vitro and in vivo function of a novel 
      small-molecule compound, FC-99, which was previously reported to have 
      immunomodulatory functions. We found that FC-99 inhibited the expression of CD40 
      and inflammatory mediators (IL-6, IL-12, and CXCL-10), as well as R848-induced 
      phosphorylation of IkappaB-alpha. We also present evidence that FC-99 is remarkably 
      efficacious in the treatment of murine lupus. Interestingly, FC-99 affected the 
      maturation and percentage of DCs in lupus-prone mice. Therefore, FC-99 may serve 
      as a potential drug candidate for treatment of SLE.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Gao, Sheng
AU  - Gao S
AD  - Laboratory Animal Center, Wenzhou Medical University, Wenzhou 325035, Zhejiang 
      Province, China.
FAU - Yuan, Linbo
AU  - Yuan L
AD  - School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, 
      Zhejiang Province, China.
FAU - Li, Cunyu
AU  - Li C
AD  - Department of Orthopedics, The Third People's Hospital of Linyi, Linyi 276000, 
      Shandong Province, China.
FAU - Han, Liping
AU  - Han L
AD  - School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, 
      Zhejiang Province, China.
FAU - Hua, Chunyan
AU  - Hua C
AD  - School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, 
      Zhejiang Province, China. Electronic address: huachunyan@wmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170328
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Alkanesulfonates)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CD40 Antigens)
RN  - 0 (Fluorocarbons)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Tlr7 protein, mouse)
RN  - 0 (Toll-Like Receptor 7)
RN  - 101027-19-4 (Fluorad FC99)
SB  - IM
MH  - Alkanesulfonates/*therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Bone Marrow Cells/physiology
MH  - CD40 Antigens/genetics/metabolism
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Dendritic Cells/drug effects/*immunology
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Female
MH  - Fluorocarbons/*therapeutic use
MH  - Humans
MH  - Immune Tolerance
MH  - Immunomodulation
MH  - Lupus Erythematosus, Systemic/*drug therapy/immunology
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Mice, Inbred MRL lpr
MH  - NF-kappa B/metabolism
MH  - Signal Transduction
MH  - Toll-Like Receptor 7/*metabolism
OTO - NOTNLM
OT  - DCs
OT  - FC-99
OT  - SLE
OT  - TLR7
EDAT- 2017/04/01 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/04/01 06:00
PHST- 2017/01/19 00:00 [received]
PHST- 2017/03/20 00:00 [revised]
PHST- 2017/03/22 00:00 [accepted]
PHST- 2017/04/01 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/04/01 06:00 [entrez]
AID - S1567-5769(17)30120-0 [pii]
AID - 10.1016/j.intimp.2017.03.023 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2017 Jun;47:47-52. doi: 10.1016/j.intimp.2017.03.023. Epub 
      2017 Mar 28.