PMID- 28363322
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20220318
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Linking)
VI  - 173 Suppl 1
DP  - 2017 Apr 1
TI  - Pain, hedonic regulation, and opioid misuse: Modulation of momentary experience 
      by Mindfulness-Oriented Recovery Enhancement in opioid-treated chronic pain 
      patients.
PG  - S65-S72
LID - S0376-8716(16)31031-6 [pii]
LID - 10.1016/j.drugalcdep.2016.07.033 [doi]
AB  - BACKGROUND: Given the risk of opioid misuse among chronic pain patients being 
      treated with long-term opioid pharmacotherapy, non-pharmacological treatments are 
      needed. Further, in light of hedonic deficits in this population, therapies that 
      enhance positive affect may be useful. The purpose of this study was to examine 
      effects of a Mindfulness-Oriented Recovery Enhancement (MORE) intervention on 
      ecological momentary assessments (EMA) of pain and positive affective experience, 
      and to determine if changes in pain, affect, and their interaction were 
      associated with opioid misuse at post-treatment. METHODS: This study examined 
      unpublished EMA data from a subset of participants (N=55) in a previously 
      published RCT (NCT01505101) of MORE versus a support group (SG) control. Across 8 
      weeks of treatment, patients completed up to 224 EMA measures of pain and affect. 
      Multilevel models and generalized estimating equations examined effects of 
      treatment on momentary pain and positive affect, and generalized linear models 
      examined associations between pain and affect and changes in opioid misuse by 
      post-treatment. RESULTS: Patients in MORE reported significantly greater 
      improvements in momentary pain (p=0.01) and positive affect (p=0.004) than 
      patients in the SG. Further, over the entire course of treatment, patients in 
      MORE were significantly more likely to exhibit positive affect regulation 
      (OR=2.75) than patients in the SG. Finally, improvements in positive affect (but 
      not pain) over the course of intervention were associated with reduced risk of 
      misusing opioids by post-treatment (p=0.02). CONCLUSION: MORE may be a useful 
      non-pharmacological treatment for pain and hedonic deficits among chronic pain 
      patients at risk for opioid misuse.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Garland, Eric L
AU  - Garland EL
AD  - University of Utah, United States. Electronic address: 
      eric.garland@socwk.utah.edu.
FAU - Bryan, Craig J
AU  - Bryan CJ
AD  - University of Utah, United States.
FAU - Finan, Patrick H
AU  - Finan PH
AD  - Johns Hopkins University, United States.
FAU - Thomas, Elizabeth A
AU  - Thomas EA
AD  - University of Utah, United States.
FAU - Priddy, Sarah E
AU  - Priddy SE
AD  - University of Utah, United States.
FAU - Riquino, Michael R
AU  - Riquino MR
AD  - University of Utah, United States.
FAU - Howard, Matthew O
AU  - Howard MO
AD  - University of North Carolina at Chapel Hill, United States.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Narcotics)
SB  - IM
MH  - Adult
MH  - Affect
MH  - Chronic Pain/*drug therapy/*psychology
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mindfulness
MH  - Narcotics/*adverse effects/*therapeutic use
MH  - Opioid-Related Disorders/*psychology/*rehabilitation
MH  - Pain Management/*methods/*psychology
MH  - Pain Measurement
MH  - *Philosophy
MH  - Self-Help Groups
MH  - Young Adult
OTO - NOTNLM
OT  - *Addiction
OT  - *Chronic pain
OT  - *Ecological momentary assessment
OT  - *Mindfulness
OT  - *Opioid misuse
OT  - *Positive affect
OT  - *Reward
EDAT- 2017/04/02 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/04/02 06:00
PHST- 2016/05/10 00:00 [received]
PHST- 2016/07/11 00:00 [revised]
PHST- 2016/07/21 00:00 [accepted]
PHST- 2017/04/02 06:00 [entrez]
PHST- 2017/04/02 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
AID - S0376-8716(16)31031-6 [pii]
AID - 10.1016/j.drugalcdep.2016.07.033 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2017 Apr 1;173 Suppl 1:S65-S72. doi: 
      10.1016/j.drugalcdep.2016.07.033.