PMID- 28363333
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20180216
IS  - 1532-2084 (Electronic)
IS  - 1368-7646 (Linking)
VI  - 30
DP  - 2017 Jan
TI  - Inverse correlation between the metastasis suppressor RKIP and the metastasis 
      inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in 
      cancer.
PG  - 28-38
LID - S1368-7646(17)30001-8 [pii]
LID - 10.1016/j.drup.2017.01.001 [doi]
AB  - Several gene products have been postulated to mediate inherent and/or acquired 
      anticancer drug resistance and tumor metastasis. Among these, the metastasis 
      suppressor and chemo-immuno-sensitizing gene product, Raf Kinase Inhibitor 
      Protein (RKIP), is poorly expressed in many cancers. In contrast, the metastasis 
      inducer and chemo-immuno-resistant factor Yin Yang 1 (YY1) is overexpressed in 
      many cancers. This inverse relationship between RKIP and YY1 expression suggests 
      that these two gene products may be regulated via cross-talks of molecular 
      signaling pathways, culminating in the expression of different phenotypes based 
      on their targets. Analyses of the molecular regulation of the expression patterns 
      of RKIP and YY1 as well as epigenetic, post-transcriptional, and 
      post-translational regulation revealed the existence of several effector 
      mechanisms and crosstalk pathways, of which five pathways of relevance have been 
      identified and analyzed. The five examined cross-talk pathways include the 
      following loops: RKIP/NF-kappaB/Snail/YY1, p38/MAPK/RKIP/GSK3beta/Snail/YY1, 
      RKIP/Smurf2/YY1/Snail, RKIP/MAPK/Myc/Let-7/HMGA2/Snail/YY1, as well as 
      RKIP/GPCR/STAT3/miR-34/YY1. Each loop is comprised of multiple interactions and 
      cascades that provide evidence for YY1's negative regulation of RKIP expression 
      and vice versa. These loops elucidate potential prognostic motifs and targets for 
      therapeutic intervention. Chiefly, these findings suggest that targeted 
      inhibition of YY1 by specific small molecule inhibitors and/or the specific 
      induction of RKIP expression and activity are potential therapeutic strategies to 
      block tumor growth and metastasis in many cancers, as well as to overcome 
      anticancer drug resistance. These strategies present potential alternatives for 
      their synergistic uses in combination with low doses of conventional 
      chemo-immunotherapeutics and hence, increasing survival, reducing toxicity, and 
      improving quality of life.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Wottrich, Stephanie
AU  - Wottrich S
AD  - Department of Microbiology, Immunology & Molecular Genetics, David Geffen School 
      of Medicine, UCLA, Los Angeles, CA, 90095, United States.
FAU - Kaufhold, Samantha
AU  - Kaufhold S
AD  - Department of Microbiology, Immunology & Molecular Genetics, David Geffen School 
      of Medicine, UCLA, Los Angeles, CA, 90095, United States.
FAU - Chrysos, Emmanuel
AU  - Chrysos E
AD  - Division of Surgical Oncology, University Hospital of Heraklion, School of 
      Medicine, University of Crete, Heraklion, 71110, Crete, Greece.
FAU - Zoras, Odysseas
AU  - Zoras O
AD  - Division of Surgical Oncology, University Hospital of Heraklion, School of 
      Medicine, University of Crete, Heraklion, 71110, Crete, Greece.
FAU - Baritaki, Stavroula
AU  - Baritaki S
AD  - Division of Surgical Oncology, University Hospital of Heraklion, School of 
      Medicine, University of Crete, Heraklion, 71110, Crete, Greece.
FAU - Bonavida, Benjamin
AU  - Bonavida B
AD  - Department of Microbiology, Immunology & Molecular Genetics, David Geffen School 
      of Medicine, UCLA, Los Angeles, CA, 90095, United States. Electronic address: 
      bbonavida@mednet.ucla.edu.
LA  - eng
GR  - R01 CA133479/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170109
PL  - Scotland
TA  - Drug Resist Updat
JT  - Drug resistance updates : reviews and commentaries in antimicrobial and 
      anticancer chemotherapy
JID - 9815369
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Phosphatidylethanolamine Binding Protein)
RN  - 0 (Transcription Factors)
RN  - 0 (YY1 Transcription Factor)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis
MH  - Drug Resistance, Neoplasm/*physiology
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Phosphatidylethanolamine Binding Protein/*biosynthesis
MH  - Signal Transduction/physiology
MH  - Transcription Factors/metabolism
MH  - YY1 Transcription Factor/*biosynthesis
OTO - NOTNLM
OT  - Cancer
OT  - Drug resistance
OT  - Immune-resistance
OT  - Raf-1 kinase inhibitory protein (RKIP)
OT  - Yin Yang 1 (YY1)
EDAT- 2017/04/02 06:00
MHDA- 2018/02/06 06:00
CRDT- 2017/04/02 06:00
PHST- 2016/11/09 00:00 [received]
PHST- 2016/12/28 00:00 [revised]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/04/02 06:00 [entrez]
PHST- 2017/04/02 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
AID - S1368-7646(17)30001-8 [pii]
AID - 10.1016/j.drup.2017.01.001 [doi]
PST - ppublish
SO  - Drug Resist Updat. 2017 Jan;30:28-38. doi: 10.1016/j.drup.2017.01.001. Epub 2017 
      Jan 9.