PMID- 2836347
OWN - NLM
STAT- MEDLINE
DCOM- 19880624
LR  - 20190510
IS  - 0910-5050 (Print)
IS  - 1876-4673 (Electronic)
IS  - 0910-5050 (Linking)
VI  - 79
IP  - 3
DP  - 1988 Mar
TI  - Levels of glutathione S transferase pi mRNA in human lung cancer cell lines 
      correlate with the resistance to cisplatin and carboplatin.
PG  - 301-4
AB  - The amounts of mRNA for glutathione S transferase pi (GST pi) were significantly 
      lower in 3 human small cell lung cancer (SCLC) cell lines than in 3 non small 
      cell lung cancer (NSCLC) cell lines. The sensitivities of the 3 SCLC cell lines 
      to cisplatin and carboplatin were much higher than those of the 3 NSCLC cell 
      lines. These results indicate that low levels of GST pi mRNA expression in SCLC 
      cell lines inversely correlate to high sensitivity to cisplatin and carboplatin, 
      and further suggest that GST pi may play an important role in intracellular 
      inactivation of these drugs.
FAU - Nakagawa, K
AU  - Nakagawa K
AD  - Pharmacology Division, National Cancer Center Research Institute, Tokyo.
FAU - Yokota, J
AU  - Yokota J
FAU - Wada, M
AU  - Wada M
FAU - Sasaki, Y
AU  - Sasaki Y
FAU - Fujiwara, Y
AU  - Fujiwara Y
FAU - Sakai, M
AU  - Sakai M
FAU - Muramatsu, M
AU  - Muramatsu M
FAU - Terasaki, T
AU  - Terasaki T
FAU - Tsunokawa, Y
AU  - Tsunokawa Y
FAU - Terada, M
AU  - Terada M
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (Organoplatinum Compounds)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA, Neoplasm)
RN  - BG3F62OND5 (Carboplatin)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Carboplatin
MH  - Carcinoma, Small Cell/drug therapy/*enzymology/metabolism
MH  - Cell Line
MH  - Cisplatin/*pharmacology
MH  - Drug Resistance
MH  - Glutathione Transferase/*metabolism
MH  - Humans
MH  - Lung Neoplasms/drug therapy/*enzymology/metabolism
MH  - Organoplatinum Compounds/*pharmacology
MH  - RNA, Messenger/*metabolism
MH  - RNA, Neoplasm/metabolism
PMC - PMC5917487
EDAT- 1988/03/01 00:00
MHDA- 1988/03/01 00:01
PMCR- 1988/03/01
CRDT- 1988/03/01 00:00
PHST- 1988/03/01 00:00 [pubmed]
PHST- 1988/03/01 00:01 [medline]
PHST- 1988/03/01 00:00 [entrez]
PHST- 1988/03/01 00:00 [pmc-release]
AID - CAE301 [pii]
AID - 10.1111/j.1349-7006.1988.tb01590.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1988 Mar;79(3):301-4. doi: 10.1111/j.1349-7006.1988.tb01590.x.