PMID- 28364278
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20181113
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 8
IP  - 7
DP  - 2017 Jul
TI  - The development and function of dendritic cell populations and their regulation 
      by miRNAs.
PG  - 501-513
LID - 10.1007/s13238-017-0398-2 [doi]
AB  - Dendritic cells (DCs) are important immune cells linking innate and adaptive 
      immune responses. DCs encounter various self and non-self antigens present in the 
      environment and induce different types of antigen specific adaptive immune 
      responses. DCs can be classified into lymphoid tissue-resident DCs, migratory 
      DCs, non-lymphoid resident DCs, and monocyte derived DCs (moDCs). Recent work has 
      also established that DCs consist of developmentally and functionally distinct 
      subsets that differentially regulate T lymphocyte function. The development of 
      different DC subsets has been found to be regulated by a network of different 
      cytokines and transcriptional factors. Moreover, the response of DC is tightly 
      regulated to maintain the homeostasis of immune system. MicroRNAs (miRNAs) are an 
      important class of cellular regulators that modulate gene expression and thereby 
      influence cell fate and function. In the immune system, miRNAs act at checkpoints 
      during hematopoietic development and cell subset differentiation, they modulate 
      effector cell function, and are implicated in the maintenance of homeostasis. DCs 
      are also regulated by miRNAs. In the past decade, much progress has been made to 
      understand the role of miRNAs in regulating the development and function of DCs. 
      In this review, we summarize the origin and distribution of different mouse DC 
      subsets in both lymphoid and non-lymphoid tissues. The DC subsets identified in 
      human are also described. Recent progress on the function of miRNAs in the 
      development and activation of DCs and their functional relevance to autoimmune 
      diseases are discussed.
FAU - Zhou, Haibo
AU  - Zhou H
AD  - Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University School of 
      Medicine, Institute of Immunology Tsinghua University, Beijing, 100084, China.
FAU - Wu, Li
AU  - Wu L
AUID- ORCID: 0000-0002-2802-1220
AD  - Tsinghua-Peking Joint Center for Life Sciences, Tsinghua University School of 
      Medicine, Institute of Immunology Tsinghua University, Beijing, 100084, China. 
      wuli@tsinghua.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170331
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/immunology
MH  - Cell Differentiation/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - MicroRNAs/*immunology
MH  - Monocytes/cytology/*immunology
MH  - T-Lymphocytes/cytology/*immunology
PMC - PMC5498339
OTO - NOTNLM
OT  - activation
OT  - autoimmune disease
OT  - dendritic cell
OT  - development
OT  - mirna
EDAT- 2017/04/02 06:00
MHDA- 2017/08/08 06:00
PMCR- 2017/03/31
CRDT- 2017/04/02 06:00
PHST- 2016/06/07 00:00 [received]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2017/04/02 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2017/04/02 06:00 [entrez]
PHST- 2017/03/31 00:00 [pmc-release]
AID - 10.1007/s13238-017-0398-2 [pii]
AID - 398 [pii]
AID - 10.1007/s13238-017-0398-2 [doi]
PST - ppublish
SO  - Protein Cell. 2017 Jul;8(7):501-513. doi: 10.1007/s13238-017-0398-2. Epub 2017 
      Mar 31.