PMID- 28364784
OWN - NLM
STAT- MEDLINE
DCOM- 20170426
LR  - 20181023
IS  - 1165-158X (Electronic)
IS  - 0145-5680 (Linking)
VI  - 63
IP  - 2
DP  - 2017 Feb 28
TI  - TTY2 genes deletions as genetic risk factor of male infertility.
PG  - 57-61
LID - 10.14715/cmb/2017.63.2.8 [doi]
AB  - Y chromosome has a number of genes that are expressed in testis and have a role 
      in spermatogenesis. TTY2L12A and TTY2L2A are the members of testis transcript Y2 
      (TTY2) that are Y linked multi-copy gene families, located on Yp11 and Yq11 loci 
      respectively. The aim of this study was to investigate frequency of TTY2L12A and 
      TTY2L2A deletions in azoospermic patients compared with fertile males. This study 
      was performed on 45 infertile males with idiopathic azoospermia without any AZF 
      micro deletions (group A), 33 infertile males with azoospermia which do not 
      screened for AZF micro deletions (group B) and 65 fertile males (group C), from 
      October 2013 to April 2015 in west of Iran. Polymerase chain reaction (PCR) 
      method was used for detection of TTY2L12A and TTY2L2A gene deletions in studied 
      groups. No deletions were detected in normal fertile males of group C. 1 out of 
      45 azoospermic males of group A (2.22%) and 3 out of 33 azoospermic males of 
      group B (9.09%) had TTY2L2A deletion (p= 0.409 and p= 0.036 respectively), also 1 
      out of 45 azoospermic males of group A (2.22%) and 4 out of 33 azoospermic males 
      of group B (12.12%) had TTY2L12A deletion (p= 0.409 and p= 0.011 respectively).  
      None of azoospermic males in Group A and B had deletions in both genes. Our data 
      showed significant correlation between non-obstructive azoospermia and TTY2L12A 
      and TTY2L2A deletions. Thus, it seems that TTY2L12A and TTY2L2A deletions can 
      consider as one of the genetic risk factors for non-obstructive azoospermia.
FAU - Shaveisi-Zadeh, F
AU  - Shaveisi-Zadeh F
AD  - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Alibakhshi, R
AU  - Alibakhshi R
AD  - Department of Biochemistry, School of Medicine, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran.
FAU - Asgari, R
AU  - Asgari R
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Rostami-Far, Z
AU  - Rostami-Far Z
AD  - Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of 
      Medical sciences, Kermanshah, Iran.
FAU - Bakhtiari, M
AU  - Bakhtiari M
AD  - Department of Anatomical Sciences and Biology, Faculty of Medicine, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Abdi, H
AU  - Abdi H
AD  - Department of Urology, School of Medicine, Kermanshah University of Medical 
      Sciences, Kermanshah, Iran.
FAU - Movafagh, A
AU  - Movafagh A
AD  - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Mirfakhraie, R
AU  - Mirfakhraie R
AD  - Department of Medical Genetics, School of Medicine, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170228
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Seminal Plasma Proteins)
RN  - 0 (TTTY2 protein, human)
SB  - IM
MH  - Adult
MH  - Azoospermia/genetics
MH  - Case-Control Studies
MH  - Chromosomes, Human, Y/genetics
MH  - *Gene Deletion
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Infertility, Male/*genetics
MH  - Iran
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Risk Factors
MH  - Seminal Plasma Proteins/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Deletion.
OT  - Male infertility
OT  - TTY2
OT  - zoospermia
EDAT- 2017/04/04 06:00
MHDA- 2017/04/27 06:00
CRDT- 2017/04/03 06:00
PHST- 2017/03/25 00:00 [received]
PHST- 2017/03/25 00:00 [accepted]
PHST- 2017/04/03 06:00 [entrez]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/04/27 06:00 [medline]
AID - 10.14715/cmb/2017.63.2.8 [doi]
PST - epublish
SO  - Cell Mol Biol (Noisy-le-grand). 2017 Feb 28;63(2):57-61. doi: 
      10.14715/cmb/2017.63.2.8.