PMID- 28365715
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20190609
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 18
DP  - 2017 Apr 2
TI  - Gall Bladder Agenesis: A Rare Embryonic Cause of Recurrent Biliary Colic.
PG  - 334-338
AB  - BACKGROUND Gallbladder agenesis (GA) is an extremely rare anatomic anomaly with a 
      reported incidence of less than 0.5%. It is usually asymptomatic, but can present 
      with features of biliary colic and cholecystitis. We present here a case of GA in 
      a patient with recurrent biliary colic.  CASE REPORT A 24-year-old African 
      American woman presented with recurrent episodes of right upper-quadrant 
      abdominal pain. During her first episode, she was found to have elevated 
      transaminases and clinical features of cholecystitis, but ultrasound did not 
      visualize a gallbladder and she was discharged with a diagnosis of biliary colic. 
      She returned within a week with worsening liver enzymes, severe pain, and 
      vomiting. A hepatobiliary iminodiacetic acid (HIDA) scan was done, which again 
      did not show the gall bladder. On clinical suspicion of acute cholecystitis, she 
      underwent laparoscopic surgery. Intraoperatively, the gall bladder fossa was 
      empty and a diagnosis of gall bladder agenesis was made. She presented a third 
      time with similar complaints and magnetic resonance cholangiopancreatography 
      (MRCP) was done, which showed normal biliary tract anatomy and absent gall 
      bladder. A diagnosis of sphincter of Oddi dysfunction was made and she was 
      discharged on antispasmodics. CONCLUSIONS Diagnosing GA is challenging. The 
      rarity of this entity combined with classic clinical features of cholecystitis 
      and non-visualization of the gall bladder on routine investigation prompts 
      unnecessary surgical intervention. Awareness of this condition, along with use of 
      better imaging modalities like preoperative MRCP, can aide physicians to 
      appropriately manage this uncommon clinical condition.
FAU - Rajkumar, Aarthi
AU  - Rajkumar A
AD  - Department of Internal Medicine, Canton Medical Education Foundation, Canton, OH, 
      USA.
AD  - Department of Internal Medicine, North East Ohio Medical university (NEOMED), 
      Rootstown, OH, USA.
FAU - Piya, Albina
AU  - Piya A
AD  - Department of Internal Medicine, Canton Medical Education Foundation, Canton, OH, 
      USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170402
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
RN  - Gallbladder, Agenesis Of
SB  - IM
MH  - Biliary Tract Diseases/*etiology
MH  - Colic/*etiology
MH  - *Congenital Abnormalities
MH  - Female
MH  - Gallbladder/*abnormalities
MH  - Humans
MH  - Rare Diseases
MH  - Recurrence
MH  - Young Adult
PMC - PMC5386428
COIS- Conflict of interest: None declared Conflict of interest The authors declare no 
      conflict of interest.
EDAT- 2017/04/04 06:00
MHDA- 2017/12/02 06:00
PMCR- 2017/04/02
CRDT- 2017/04/03 06:00
PHST- 2017/04/03 06:00 [entrez]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
PHST- 2017/04/02 00:00 [pmc-release]
AID - 903176 [pii]
AID - 10.12659/ajcr.903176 [doi]
PST - epublish
SO  - Am J Case Rep. 2017 Apr 2;18:334-338. doi: 10.12659/ajcr.903176.