PMID- 28365812 OWN - NLM STAT- MEDLINE DCOM- 20180430 LR - 20221207 IS - 1435-5604 (Electronic) IS - 0914-8779 (Linking) VI - 36 IP - 2 DP - 2018 Mar TI - Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. PG - 246-253 LID - 10.1007/s00774-017-0834-7 [doi] AB - To purpose of this study was to reveal the mean levels and positive proportion of serological markers related to rheumatoid arthritis, and clarify their relationship with osteoporosis and hand osteoarthritis (OA). A total of 1546 participants from the third survey of the research on osteoarthritis/osteoporosis against disability study were enrolled in the current study. Using participant blood samples, the levels of anti-cyclic citrullinated protein (CCP) antibody, rheumatoid factor (RF), matrix metalloproteinase-3 (MMP-3), C-reactive protein (CRP), and high-sensitivity CRP (hsCRP) were measured. Subjects with higher than normal levels were defined as being positive. Osteoporosis was defined according to the recommendations set by World Health Organization criteria in 1994. Radiographic hand OA was evaluated using the modified Kellgren-Lawrence (KL) scale. The positive proportion of anti-CCP antibody, RF, MMP-3, CRP, and hsCRP was 1.8, 7.1, 15.0, 6.7, and 6.4%, respectively. MMP-3 was associated with age, and was significantly higher in men than in women. Positive MMP-3 was not significantly related to osteoporosis or severe hand OA (KL grade >/=3) after adjustment for other factors including age, sex, and body mass index. The results from this study clarified the values and positive proportion of RA-related markers and revealed their relationship with osteoporosis and hand OA. FAU - Kodama, Rie AU - Kodama R AD - Department of Orthopedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. FAU - Muraki, Shigeyuki AU - Muraki S AD - Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan. FAU - Iidaka, Toshiko AU - Iidaka T AD - Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan. FAU - Oka, Hiroyuki AU - Oka H AD - Department of Medical Research and Management for Musculoskeletal Pain, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. FAU - Teraguchi, Masatoshi AU - Teraguchi M AD - Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan. FAU - Kagotani, Ryohei AU - Kagotani R AD - Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan. FAU - Asai, Yoshiki AU - Asai Y AD - Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan. FAU - Hashizume, Hiroshi AU - Hashizume H AD - Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan. FAU - Yoshida, Munehito AU - Yoshida M AD - Department of Orthopedic Surgery, Wakayama Medical University, Wakayama, Japan. FAU - Kawaguchi, Hiroshi AU - Kawaguchi H AD - Department of Orthopedic Surgery, Japan Community Healthcare Organization Tokyo Shinjuku Medical Center, Tokyo, Japan. FAU - Nakamura, Kozo AU - Nakamura K AD - National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. FAU - Akune, Toru AU - Akune T AD - National Rehabilitation Center for Persons with Disabilities, Saitama, Japan. FAU - Tanaka, Sakae AU - Tanaka S AD - Department of Orthopedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. FAU - Yoshimura, Noriko AU - Yoshimura N AD - Department of Joint Disease Research, 22nd Century Medical and Research Center, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan. yoshimuran-ort@h.u-tokyo.ac.jp. LA - eng GR - H17-Men-eki-009/The Ministry of Health, Labour and Welfare/ GR - H20-Choujyu-009/The Ministry of Health, Labour and Welfare/ GR - H23-Choujyu-002/The Ministry of Health, Labour and Welfare/ GR - H25-Nanchitou(Men)-005/The Ministry of Health, Labour and Welfare/ GR - H-25-Choujyu-007/The Ministry of Health, Labour and Welfare/ GR - Scientific Research B26293139, B23390172, B20390182, and Challenging Exploratory Research 24659317/The Ministry of Education, Culture, Sports, Science and Technology in Japan/ GR - B23390356, C20591774, and Challenging Exploratory Research 23659580/The Ministry of Education, Culture, Sports, Science and Technology in Japan/ GR - Challenging Exploratory Research 24659666 and 21659349 and Young Scientists A18689031/The Ministry of Education, Culture, Sports, Science and Technology in Japan/ GR - B23390357 and C20591737/The Ministry of Education, Culture, Sports, Science and Technology in Japan/ GR - JOA-Subsidized Science Project Research 2006-1 & 2010-2/The Japanese Orthopaedic Association/ PT - Journal Article DEP - 20170401 PL - Japan TA - J Bone Miner Metab JT - Journal of bone and mineral metabolism JID - 9436705 RN - 0 (Autoantibodies) RN - 0 (Biomarkers) RN - 0 (Peptides, Cyclic) RN - 9007-41-4 (C-Reactive Protein) RN - 9009-79-4 (Rheumatoid Factor) RN - EC 3.4.24.17 (MMP3 protein, human) RN - EC 3.4.24.17 (Matrix Metalloproteinase 3) SB - IM MH - Aged MH - Arthritis, Rheumatoid/*blood MH - *Asian People MH - Autoantibodies/*blood MH - Biomarkers/blood MH - C-Reactive Protein/metabolism MH - Female MH - Humans MH - Male MH - Matrix Metalloproteinase 3/*blood MH - Middle Aged MH - Osteoarthritis/*blood MH - Osteoporosis/*blood MH - Peptides, Cyclic/blood MH - Rheumatoid Factor/blood OTO - NOTNLM OT - Biomarkers OT - Matrix metalloproteinase-3 OT - Osteoarthritis OT - Osteoporosis OT - Rheumatoid arthritis EDAT- 2017/04/04 06:00 MHDA- 2018/05/01 06:00 CRDT- 2017/04/03 06:00 PHST- 2017/02/07 00:00 [received] PHST- 2017/03/12 00:00 [accepted] PHST- 2017/04/04 06:00 [pubmed] PHST- 2018/05/01 06:00 [medline] PHST- 2017/04/03 06:00 [entrez] AID - 10.1007/s00774-017-0834-7 [pii] AID - 10.1007/s00774-017-0834-7 [doi] PST - ppublish SO - J Bone Miner Metab. 2018 Mar;36(2):246-253. doi: 10.1007/s00774-017-0834-7. Epub 2017 Apr 1.