PMID- 28366584
OWN - NLM
STAT- MEDLINE
DCOM- 20170804
LR  - 20171205
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 118
IP  - 5
DP  - 2017 May
TI  - Control of Allergic Rhinitis and Asthma Test for Children (CARATKids): Validation 
      in Brazil and cutoff values.
PG  - 551-556.e2
LID - S1081-1206(17)30109-6 [pii]
LID - 10.1016/j.anai.2017.02.007 [doi]
AB  - BACKGROUND: The Control of Allergic Rhinitis and Asthma Test for Children 
      (CARATKids) assesses asthma and allergic rhinitis control in children younger 
      than 12 years. OBJECTIVE: To validate the Brazilian Portuguese version of the 
      CARATKids and to define the cutoff values for identifying uncontrolled disease. 
      METHODS: Children aged 6 to 12 years with asthma and allergic rhinitis were 
      studied (n = 102). CARATKids, childhood Asthma Control Test (cACT), total nasal 
      symptom score (TNSS), and visual analog scale (VAS) scores were obtained at 
      baseline and after 4 to 6 weeks. Internal consistency, test-retest reliability, 
      responsiveness, and validity of the Brazilian CARATKids were assessed according 
      to the Consensus-based Standards for the Selection of Health Measurements 
      Instruments checklist. The minimal clinically important difference (MCID) was 
      evaluated using distribution and anchor methods. Spearman correlations were used 
      to compare CARATKids scores with external measures of control. Receiver operating 
      characteristic curve analysis was performed to establish cutoff values. RESULTS: 
      Fifty children completed both visits. The Cronbach alpha and intraclass correlation 
      coefficient of CARATKids were 0.81 and 0.85, respectively. The Guyatt 
      responsiveness index was -1.34, and within-patient change in clinically unstable 
      patients (n = 31) was significant (P = .02). As for cross-sectional and 
      longitudinal validity, correlation coefficients ranged from 0.58 to 0.77 (P < 
      .001) and 0.30 to 0.57 (P < .05), respectively. The estimated MCID for CARATKids 
      was 3. The optimal cutoffs (sensitivity and specificity) to exclude uncontrolled 
      and controlled disease were 3 or less (97% and 67%) and 6 or greater (56% and 
      96%), respectively. CONCLUSION: CARATKids is a reliable and valid tool to assess 
      asthma and allergic rhinitis control in Brazilian children. A score of 6 or 
      higher on CARATKids identifies uncontrolled disease, and a score of 3 or lower 
      excludes poor disease control.
CI  - Copyright (c) 2017 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Amaral, Rita
AU  - Amaral R
AD  - Centre for Research in Health Technologies and Information Systems, Faculty of 
      Medicine, University of Porto, Porto, Portugal; Allergy Unit, CUF Porto Institute 
      and Hospital, Porto, Portugal.
FAU - Carneiro, Ana C
AU  - Carneiro AC
AD  - Federal University of Sao Paulo, Sao Paulo, Brazil; Escola Paulista de Medicina, 
      Sao Paulo, SP, Brazil.
FAU - Wandalsen, Gustavo
AU  - Wandalsen G
AD  - Federal University of Sao Paulo, Sao Paulo, Brazil; Escola Paulista de Medicina, 
      Sao Paulo, SP, Brazil.
FAU - Fonseca, Joao A
AU  - Fonseca JA
AD  - Centre for Research in Health Technologies and Information Systems, Faculty of 
      Medicine, University of Porto, Porto, Portugal; Allergy Unit, CUF Porto Institute 
      and Hospital, Porto, Portugal. Electronic address: fonseca.ja@gmail.com.
FAU - Sole, Dirceu
AU  - Sole D
AD  - Federal University of Sao Paulo, Sao Paulo, Brazil; Escola Paulista de Medicina, 
      Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170331
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Asthma/*diagnosis/epidemiology/prevention & control
MH  - Brazil
MH  - Child
MH  - Child, Preschool
MH  - *Diagnostic Tests, Routine/methods/standards
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - ROC Curve
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Rhinitis, Allergic/*diagnosis/epidemiology/prevention & control
MH  - Self Report
MH  - Surveys and Questionnaires
EDAT- 2017/04/04 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/04/04 06:00
PHST- 2016/11/02 00:00 [received]
PHST- 2017/01/16 00:00 [revised]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/08/05 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - S1081-1206(17)30109-6 [pii]
AID - 10.1016/j.anai.2017.02.007 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2017 May;118(5):551-556.e2. doi: 
      10.1016/j.anai.2017.02.007. Epub 2017 Mar 31.