PMID- 28367350
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2090-6943 (Print)
IS  - 2090-6951 (Electronic)
IS  - 2090-6951 (Linking)
VI  - 2017
DP  - 2017
TI  - Immune Reconstitution Inflammatory Syndrome Occurring in a Kidney Transplant 
      Patient with Extrapulmonary Tuberculosis.
PG  - 6290987
LID - 10.1155/2017/6290987 [doi]
LID - 6290987
AB  - Tuberculosis (TB) occurring in solid organ transplantation (SOT) is associated 
      with significant morbidity and mortality usually due to delays in diagnosis, drug 
      toxicity encountered with antimycobacterial therapy, and drug-drug interactions. 
      TB in SOT patients may mimic other infectious and noninfectious posttransplant 
      complications such as posttransplant lymphoproliferative disorder (PTLD) and 
      systemic cytomegalovirus infection. Immune reconstitution inflammatory syndrome 
      (IRIS) is a host response resulting in paradoxical worsening of an infectious 
      disease which occurs after the employment of effective therapy and reversal of an 
      immunosuppressed state. We describe the development of immune reconstitution 
      inflammatory syndrome (IRIS), a unique complication occurring during the 
      treatment of extrapulmonary tuberculosis occurring after transplant which 
      resulted from decreasing immunosuppression in a patient who received Alemtuzumab 
      induction therapy. Although (IRIS) has been originally described in HIV/AIDS 
      patients receiving highly active antiretroviral therapy (HAART), solid organ 
      transplant recipients with diagnosed or occult TB whose immune system may undergo 
      immune reconstitution during their posttransplant course represent a new high 
      risk group.
FAU - Iglesias, Jose
AU  - Iglesias J
AUID- ORCID: 0000-0001-7851-0498
AD  - Department of Nephrology, Jersey Shore University Medical Center, Neptune, NJ 
      07753, USA; Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, 
      USA.
FAU - Ledesma, Kandria Jumil
AU  - Ledesma KJ
AD  - American University of Antigua College of Medicine, Coolidge, Antigua and 
      Barbuda.
FAU - Couto, Paul J
AU  - Couto PJ
AUID- ORCID: 0000-0002-1106-9404
AD  - American University of Antigua College of Medicine, Coolidge, Antigua and 
      Barbuda.
FAU - Liu, Jessie
AU  - Liu J
AD  - Ocean Renal Associates, 210 Jack Martin Boulevard, Brick, NJ 08724, USA.
LA  - eng
PT  - Case Reports
DEP - 20170307
PL  - United States
TA  - Case Rep Transplant
JT  - Case reports in transplantation
JID - 101591863
PMC - PMC5359457
EDAT- 2017/04/04 06:00
MHDA- 2017/04/04 06:01
PMCR- 2017/03/07
CRDT- 2017/04/04 06:00
PHST- 2016/11/07 00:00 [received]
PHST- 2017/02/22 00:00 [accepted]
PHST- 2017/04/04 06:00 [entrez]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/04/04 06:01 [medline]
PHST- 2017/03/07 00:00 [pmc-release]
AID - 10.1155/2017/6290987 [doi]
PST - ppublish
SO  - Case Rep Transplant. 2017;2017:6290987. doi: 10.1155/2017/6290987. Epub 2017 Mar 
      7.