PMID- 28367656
OWN - NLM
STAT- MEDLINE
DCOM- 20170707
LR  - 20170707
IS  - 1532-432X (Electronic)
IS  - 0363-0269 (Linking)
VI  - 41
IP  - 1
DP  - 2017 Jan
TI  - Prevalence of Anemia and Hemoglobin Disorders Among School Children in Myanmar.
PG  - 26-31
LID - 10.1080/03630269.2017.1289103 [doi]
AB  - The prevalence of anemia is high in the population of Myanmar and hypochromic 
      microcytic anemia (HMA) is predominant. The objective of our study was to 
      determine the prevalence of anemia and causes of HMA among school children. A 
      cross-sectional study was conducted on 239 children from Thanlyin and Insein 
      Townships, Yangon Region, Myanmar. Complete blood count (CBC) and blood film 
      morphology was examined on venous blood samples. Hypochromic microcytic anemia 
      cases were subsequently analyzed for serum ferritin and cellulose acetate 
      hemoglobin (Hb) electrophoresis. The prevalence of anemia was 46.4%; 27.6% had 
      mild, while 18.8% had moderate anemia, and no case of severe anemia was detected. 
      The mean Hb concentration was 11.7 +/- 0.9 g/dL. The younger age group (8-11 years) 
      had a significantly higher prevalence of anemia than the older age group 
      (12-15 years) (p = 0.029). Blood film morphology revealed a 50.6% red blood cell 
      (RBC) disorder; HMA was the most common type (70.2%). Out of 85 children with 
      HMA, three children (3.5%) had iron deficiency and all had comorbidity with Hb AE 
      (beta(A)/beta(E)) (Hb E trait). Hemoglobin electrophoresis illustrated that Hb AA 
      (beta(A)/beta(A)) (31, 36.5%) and Hb AE (beta(A)/beta(E)) trait (31, 36.5%) were the most 
      common types followed by beta-thalassemia (beta-thal) trait (19, 22.3%) and Hb EE 
      (beta(E)/beta(E)) (homozygous Hb E; HBB: c.79G>A) (three, 3.5%). Hematocrit [or packed 
      cell volume (PCV)], mean corpuscular volume (MCV), mean corpuscular Hb (MCH) and 
      mean corpuscular Hb concentration (MCHC), showed a significant difference between 
      Hb AE, Hb EE and beta-thal trait (p = 0.029, 0.023, 0.015 and 0.01, respectively). 
      Our findings will provide valuable information for the management of anemia in 
      the Myanmar school-age population.
FAU - Wah, Saw Thu
AU  - Wah ST
AD  - a Department of Clinical Microscopy, Faculty of Medical Technology , Mahidol 
      University , Bangkok , Thailand.
AD  - b Department of Medical Laboratory Technology , University of Medical Technology 
      , Yangon , Myanmar.
FAU - Yi, Yoon Shwe
AU  - Yi YS
AD  - b Department of Medical Laboratory Technology , University of Medical Technology 
      , Yangon , Myanmar.
FAU - Khin, Aye Aye
AU  - Khin AA
AD  - b Department of Medical Laboratory Technology , University of Medical Technology 
      , Yangon , Myanmar.
FAU - Plabplueng, Chotiros
AU  - Plabplueng C
AD  - a Department of Clinical Microscopy, Faculty of Medical Technology , Mahidol 
      University , Bangkok , Thailand.
AD  - c Center for Research and Innovation, Faculty of Medical Technology , Mahidol 
      University , Bangkok , Thailand.
FAU - Nuchnoi, Pornlada
AU  - Nuchnoi P
AD  - a Department of Clinical Microscopy, Faculty of Medical Technology , Mahidol 
      University , Bangkok , Thailand.
AD  - c Center for Research and Innovation, Faculty of Medical Technology , Mahidol 
      University , Bangkok , Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170402
PL  - England
TA  - Hemoglobin
JT  - Hemoglobin
JID - 7705865
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Anemia/diagnosis/*epidemiology
MH  - Biomarkers
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - Hemoglobinopathies/diagnosis/*epidemiology
MH  - Humans
MH  - Male
MH  - Myanmar/epidemiology
MH  - Prevalence
MH  - *Public Health Surveillance
MH  - Schools
MH  - Severity of Illness Index
MH  - Students
MH  - Workflow
OTO - NOTNLM
OT  - Anemia
OT  - Myanmar
OT  - hemoglobinopathies
OT  - iron deficiency
OT  - thalassemia
EDAT- 2017/04/04 06:00
MHDA- 2017/07/08 06:00
CRDT- 2017/04/04 06:00
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/07/08 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 10.1080/03630269.2017.1289103 [doi]
PST - ppublish
SO  - Hemoglobin. 2017 Jan;41(1):26-31. doi: 10.1080/03630269.2017.1289103. Epub 2017 
      Apr 2.