PMID- 28367948
OWN - NLM
STAT- MEDLINE
DCOM- 20170614
LR  - 20171012
IS  - 1882-0654 (Electronic)
IS  - 0009-918X (Linking)
VI  - 57
IP  - 4
DP  - 2017 Apr 28
TI  - [Human herpesvirus 6 encephalitis followed by acute disseminated 
      encephalomyelitis in an immunocompetent adult].
PG  - 174-179
LID - 10.5692/clinicalneurol.cn-000992 [doi]
AB  - A 26-year-old, otherwise healthy man presented with visual abnormality followed 
      by loss of consciousness and convulsion. The patient then developed headache and 
      fever 14 days later. Brain MRI showed hyperintensities in the left cingulate 
      cortex. The cerrebrospinal fluid examinations showed mononuclear pleocytosis and 
      positive PCR results for human herpesvirus 6 (HHV-6). A diagnosis of HHV-6 
      encephalitis and symptomatic epilepsy was made. The patient's clinical symptoms 
      improved promptly following acyclovir treatment. However, 3 months later the 
      patient noticed dysesthesia in the trunk, the left upper limb and the right lower 
      limb. Brain and spine MRI showed multiple brain white matter lesions, the middle 
      cerebellar peduncle and cervical spinal lesions. The symptoms resolved following 
      methylprednisolone pulse therapy only. We report an adult patient with HHV-6 
      encephalitis followed by acute disseminated encephalomyelitis whose initial 
      presentation was epilepsy. HHV-6 encephalitis should be included in the 
      differential diagnosis of encephalitis of unknown etiology in an immunocompetent 
      adult.
FAU - Horie, Junichi
AU  - Horie J
AD  - Department of Neurology, Dokkyo Medical University.
FAU - Suzuki, Keisuke
AU  - Suzuki K
AD  - Department of Neurology, Dokkyo Medical University.
FAU - Nakamura, Toshiki
AU  - Nakamura T
AD  - Department of Neurology, Rehabilitation Amakusa Hospital.
FAU - Okamura, Madoka
AU  - Okamura M
AD  - Department of Neurology, Dokkyo Medical University.
FAU - Iwasaki, Akio
AU  - Iwasaki A
AD  - Department of Neurology, Dokkyo Medical University.
FAU - Hirata, Koichi
AU  - Hirata K
AD  - Department of Neurology, Dokkyo Medical University.
LA  - jpn
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20170330
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
RN  - 0 (Biomarkers)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Adult
MH  - Biomarkers/cerebrospinal fluid
MH  - Brain/diagnostic imaging
MH  - Cervical Vertebrae
MH  - Encephalitis/*diagnosis/drug therapy/*virology
MH  - Encephalomyelitis, Acute Disseminated/drug therapy/*etiology
MH  - Epilepsy/drug therapy/etiology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - *Immunocompetence
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methylprednisolone/administration & dosage
MH  - Pulse Therapy, Drug
MH  - *Roseolovirus Infections
MH  - Spinal Cord/diagnostic imaging
MH  - Treatment Outcome
OTO - NOTNLM
OT  - HHV-6 encephalitis
OT  - acute disseminated encephalomyelitis
OT  - epilepsy
OT  - immunocompetent adult
EDAT- 2017/04/04 06:00
MHDA- 2017/06/15 06:00
CRDT- 2017/04/04 06:00
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/06/15 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 10.5692/clinicalneurol.cn-000992 [doi]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2017 Apr 28;57(4):174-179. doi: 
      10.5692/clinicalneurol.cn-000992. Epub 2017 Mar 30.