PMID- 28368218
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20180522
IS  - 1473-0766 (Electronic)
IS  - 0951-3590 (Linking)
VI  - 33
IP  - 8
DP  - 2017 Aug
TI  - Fine-particulate matter (PM2.5), a risk factor for rat gestational diabetes with 
      altered blood glucose and pancreatic GLUT2 expression.
PG  - 611-616
LID - 10.1080/09513590.2017.1301923 [doi]
AB  - Recent studies have shown an intriguing association between air pollution and 
      diabetic risk. This study was to investigate the impact of fine particulate 
      matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) 
      expression in a gestational diabetes mellitus (GDM) rat model. GDM rats were 
      exposed to a low PM2.5 dose during pregnancy. After exposure, interleukin-6 
      (IL-6) and blood routine tests (BRT) were detected. Pancreas underwent pathologic 
      examination. The levels of pancreatic homogenate glutathione peroxidase (GSH-Px), 
      methane dicarboxylic aldehyde (MDA) and GLUT2 were detected. There were lower 
      maternal body weight gain and fetal weight in the PM2.5 group. Exposure to PM2.5 
      caused increased absorbed blastocyst number, higher blood mono-nuclear cells 
      (PBMC), platelets and IL-6 levels. The postprandial blood glucose (PBG) was 
      elevated at most time points after exposure. The pancreas of PM2.5 exposed rats 
      revealed periductal inflammation under pathological examination. The pancreatic 
      GSH-Px significantly reduced and MDA increased in exposed group. The pancreatic 
      GLUT2 expression was decreased after PM2.5 exposure. Our study provides direct 
      evidence that PM2.5 exposure can result in pancreatic pathological changes and 
      glycemic consequences in GDM rats. The oxidative response and inflammation are 
      involved in PM2.5 increased risk of pancreatic impairment and glycemic 
      consequences.
FAU - Yi, Liu
AU  - Yi L
AD  - a Department of Gynaecology and Obstetrics , The Second Affiliated Hospital of 
      Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, 
      China.
FAU - Wei, Chen
AU  - Wei C
AD  - b Department of Urological Surgery , The First Affiliated Hospital of Wenzhou 
      Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, China.
FAU - Fan, Wang
AU  - Fan W
AD  - c Department of Gynaecology and Obstetrics , The Second Affiliated Hospital of 
      Wenzhou Medical University , Wenzhou, Zhejiang Province , P. R. China , Wenzhou, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20170403
PL  - England
TA  - Gynecol Endocrinol
JT  - Gynecological endocrinology : the official journal of the International Society 
      of Gynecological Endocrinology
JID - 8807913
RN  - 0 (Air Pollutants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glucose Transporter Type 2)
RN  - 0 (Interleukin-6)
RN  - 0 (Particulate Matter)
RN  - 0 (Slc2a2 protein, rat)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Animals
MH  - Biomarkers/blood/metabolism
MH  - Blood Cell Count
MH  - Blood Glucose/analysis
MH  - Diabetes, Gestational/*chemically induced/immunology/metabolism/pathology
MH  - Female
MH  - Fetal Resorption/chemically induced
MH  - Gene Expression Regulation/*drug effects
MH  - Glucose Transporter Type 2/genetics/*metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Interleukin-6/blood
MH  - Leukocytosis/chemically induced
MH  - Maternal Exposure/*adverse effects
MH  - Oxidative Stress/drug effects
MH  - Pancreas/*drug effects/immunology/metabolism/pathology
MH  - Particulate Matter/*toxicity
MH  - Pregnancy
MH  - Random Allocation
MH  - Rats, Sprague-Dawley
MH  - Thrombocytosis/chemically induced
MH  - Weight Gain/drug effects
OTO - NOTNLM
OT  - Blood glucose
OT  - gestational diabetes mellitus
OT  - glucose transporter 2
OT  - particulate matter
EDAT- 2017/04/04 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/04/04 06:00
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 10.1080/09513590.2017.1301923 [doi]
PST - ppublish
SO  - Gynecol Endocrinol. 2017 Aug;33(8):611-616. doi: 10.1080/09513590.2017.1301923. 
      Epub 2017 Apr 3.