PMID- 28368353
OWN - NLM
STAT- MEDLINE
DCOM- 20170817
LR  - 20181202
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 14
IP  - 4
DP  - 2017 Apr 3
TI  - The Prevalence of Hypertension Accompanied by High Homocysteine and its Risk 
      Factors in a Rural Population: A Cross-Sectional Study from Northeast China.
LID - 10.3390/ijerph14040376 [doi]
LID - 376
AB  - Previous studies found that hypertension and high homocysteine (HHcy) exhibited a 
      synergistic effect on the risk of cardiovascular diseases. This study aimed to 
      investigate the prevalence of hypertension accompanied by HHcy and its risk 
      factors in the rural areas of northeast China. This study was conducted using a 
      stratified cluster random sampling method, and included 6529 subjects with 
      complete data. Demographic characteristics were obtained from a questionnaire. 
      Blood pressure and anthropometric indices were measured, and serum indices were 
      analyzed. Hypertension accompanied by HHcy was defined as hypertension plus HHcy 
      [homocysteine (Hcy) > 10 micromol/L]. The mean concentration of Hcy was 17.29 mumol/L 
      in the general population. The prevalence of hypertension accompanied by HHcy was 
      so high that it reached 45.1% of our study population and accounted for 86.8% of 
      the total participants with hypertension. Multiple logistic regression analysis 
      indicated that the modifiable risk factors of hypertension accompanied by HHcy 
      included obesity, diabetes, dyslipidemia, and inactive physical activities. We 
      found that the mean level of Hcy, and the prevalences of HHcy and hypertension 
      accompanied by HHcy were very high among the rural population of northeast China. 
      Obesity, diabetes, dyslipidemia, and inactive physical activities were modifiable 
      risk factors of hypertension accompanied by HHcy.
FAU - Chang, Ye
AU  - Chang Y
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. chang.ye@stu.xjtu.edu.cn.
FAU - Li, Yuan
AU  - Li Y
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. xi.aohan1989@163.com.
FAU - Guo, Xiaofan
AU  - Guo X
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. guoxiaofan1986@foxmail.com.
FAU - Chen, Yintao
AU  - Chen Y
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. chenyintao1990@126.com.
FAU - Dai, Dongxue
AU  - Dai D
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. 18240409506@163.com.
FAU - Sun, Yingxian
AU  - Sun Y
AD  - Department of Cardiology, the First Hospital of China Medical University, 
      Shenyang 110001, China. yxsun@mail.cmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170403
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Homocysteine/blood
MH  - Humans
MH  - Hyperhomocysteinemia/complications/*epidemiology
MH  - Hypertension/complications/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Rural Population
PMC - PMC5409577
OTO - NOTNLM
OT  - cross-sectional study
OT  - homocysteine
OT  - hypertension
OT  - rural population
COIS- The authors declare no conflict of interest.
EDAT- 2017/04/04 06:00
MHDA- 2017/08/18 06:00
PMCR- 2017/04/01
CRDT- 2017/04/04 06:00
PHST- 2017/01/07 00:00 [received]
PHST- 2017/03/29 00:00 [revised]
PHST- 2017/04/01 00:00 [accepted]
PHST- 2017/04/04 06:00 [entrez]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/08/18 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - ijerph14040376 [pii]
AID - ijerph-14-00376 [pii]
AID - 10.3390/ijerph14040376 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2017 Apr 3;14(4):376. doi: 
      10.3390/ijerph14040376.