PMID- 28369180
OWN - NLM
STAT- MEDLINE
DCOM- 20170424
LR  - 20170711
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 185
IP  - 8
DP  - 2017 Apr 15
TI  - Possible Interaction Between Cigarette Smoking and HLA-DRB1 Variation in the Risk 
      of Follicular Lymphoma.
PG  - 681-687
LID - 10.1093/aje/kww118 [doi]
AB  - Follicular lymphoma (FL) risk is strongly associated with germline genetic 
      variation in human leukocyte antigen (HLA) class II. Cigarette smoking has been 
      suggested to increase FL risk, primarily among women. We hypothesized that amino 
      acids in HLA-antigen D-related beta1 subunit (DRB1) interact with smoking in FL 
      risk, as shown for rheumatoid arthritis. We analyzed 373 patients with FL and 818 
      controls from 2 population-based case-control studies in Sweden and Denmark 
      (1999-2003). Haplotypes in HLA-DRB1 were imputed at amino acid positions 11, 13, 
      28, 30, and 70-74 (shared epitope). We estimated the relative risk of FL as odds 
      ratios with 95% confidence intervals for different smoking status/haplotype 
      combinations. Interaction was defined as departure from additivity of effects and 
      quantified by the attributable proportion (AP). Relative to never-smokers 
      carrying no shared epitope alleles, smoking was associated with the risk of FL 
      among all subjects (for former smokers, odds ratio (OR) = 2.20, 95% confidence 
      interval (CI): 1.10, 4.41; ORcurrent = 3.56, 95% CI: 1.60, 7.92) and women 
      (ORformer = 2.95, 95% CI: 1.18, 7.37; ORcurrent = 5.63, 95% CI: 2.07, 15.3) 
      carrying 2 shared epitope alleles but not among those carrying zero or 1 shared 
      epitope allele. Smoking and shared epitope status interacted significantly as 
      measured by AP (overall, AP = 0.6, 95% CI: 0.15, 1.0; for women, AP = 0.5, 95% 
      CI: 0.005, 1.0). These results suggest a possible interaction between smoking and 
      HLA-DRB1-associated antigen presentation in FL risk and provide a model to 
      further unravel FL etiology.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of the Johns 
      Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Baecklund, Fredrik
AU  - Baecklund F
AD  - Clinical Epidemiology Unit T2, Department of Medicine, Solna, Karolinska 
      Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.
FAU - Foo, Jia-Nee
AU  - Foo JN
AD  - Human Genetics, Genome Institute of Singapore, A*STAR, Singapore.
FAU - Askling, Johan
AU  - Askling J
AD  - Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Eloranta, Sandra
AU  - Eloranta S
AD  - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 
      Stockholm, Sweden.
FAU - Glimelius, Ingrid
AU  - Glimelius I
AD  - Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet and 
      Karolinska University Hospital, Stockholm, Sweden.
AD  - Department of Immunology, Genetics and Pathology, Clinical and Experimental 
      Oncology, Uppsala University and Uppsala Akademiska Hospital, Sweden.
FAU - Liu, Jianjun
AU  - Liu J
AD  - School of Health Sciences, Wuhan University, Wuhan, 430071, China.
FAU - Hjalgrim, Henrik
AU  - Hjalgrim H
AD  - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; 
      Department of Hematology, Copenhagen University Hospital, Copenhagen, Denmark.
FAU - Rosenquist, Richard
AU  - Rosenquist R
AD  - Department of Immunology, Genetics and Pathology , Uppsala University , Uppsala , 
      Sweden.
FAU - Padyukov, Leonid
AU  - Padyukov L
AD  - Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska 
      University Hospital, Stockholm, Sweden.
FAU - Smedby, Karin E
AU  - Smedby KE
AD  - Department of Medicine Solna, Clinical Epidemiology Unit, Karolinska Institutet, 
      Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Denmark/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genetic Variation
MH  - HLA-DRB1 Chains/*genetics/physiology
MH  - Haplotypes/genetics
MH  - Humans
MH  - Lymphoma, Follicular/epidemiology/etiology/*genetics
MH  - Male
MH  - Risk Factors
MH  - Smoking/*adverse effects
MH  - Sweden/epidemiology
OTO - NOTNLM
OT  - HLA-DRB1
OT  - etiology
OT  - follicular lymphoma
OT  - interaction
OT  - smoking
EDAT- 2017/04/04 06:00
MHDA- 2017/04/25 06:00
CRDT- 2017/04/04 06:00
PHST- 2016/01/02 00:00 [received]
PHST- 2016/03/24 00:00 [accepted]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2017/04/25 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 3091718 [pii]
AID - 10.1093/aje/kww118 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2017 Apr 15;185(8):681-687. doi: 10.1093/aje/kww118.