PMID- 28370416
OWN - NLM
STAT- MEDLINE
DCOM- 20180418
LR  - 20180418
IS  - 1540-8175 (Electronic)
IS  - 0742-2822 (Linking)
VI  - 34
IP  - 6
DP  - 2017 Jun
TI  - Right ventricular function and N-terminal pro-brain natriuretic peptide levels in 
      adult patients with simple dextro-transposition of the great arteries.
PG  - 876-880
LID - 10.1111/echo.13526 [doi]
AB  - INTRODUCTION: Dextro-transposition of the great arteries (d-TGA) patients is at 
      high risk of developing right ventricular dysfunction and tricuspid regurgitation 
      in adulthood. Determining the relation between echocardiographic parameters, 
      N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels and the New York 
      Heart Association (NYHA) functional class may help determining the best time to 
      operate them. METHODS: Patients with simple d-TGA operated in infancy with an 
      atrial switch procedure (Mustard or Senning operation) were followed up in our 
      Adult Congenital Heart Disease Unit. Analytical, echocardiographic, and clinical 
      parameters were determined to evaluate the correlation between right 
      echocardiographic ventricular function, NT-pro-BNP levels, and NYHA functional 
      class. RESULTS: Twenty-four patients with d-TGA were operated in infancy of whom 
      17 alive patients had simple d-TGA. Nine patients had NT-pro-BNP levels lower 
      than 200 pg/mL and eight patients were above 200 pg/mL. Patients with lower 
      hemoglobin concentration, higher right ventricular diameter or under diuretic 
      treatment showed significant higher NT-pro-BNP levels (above 200 pg/dL). The 
      Spearman test showed a positive correlation between basal right ventricular 
      diameter and tricuspid regurgitation with pro NT BNP levels (correlation 
      coefficient of .624; P=.017 and .490; P=.046, respectively) and a negative 
      correlation with the right ventricle fractional area change (-.508, P=.045). No 
      correlation was seen between NT-pro-BNP levels and the rest of echocardiographic 
      parameters or the NYHA functional class. CONCLUSION: NT-pro-BNP levels showed a 
      positive correlation with basal right ventricular diameter and tricuspid 
      regurgitation but not with NYHA association functional class in d-TGA patients.
CI  - (c) 2017, Wiley Periodicals, Inc.
FAU - Martinez-Quintana, Efren
AU  - Martinez-Quintana E
AUID- ORCID: 0000-0002-1289-7279
AD  - Cardiology Service, Insular-Materno Infantil University Hospital, Las Palmas de 
      Gran Canaria, Spain.
AD  - Department of Medical and Surgical Sciences, Faculty of Health Sciences, 
      University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
FAU - Marrero-Negrin, Natalia
AU  - Marrero-Negrin N
AD  - Cardiology Service, Insular-Materno Infantil University Hospital, Las Palmas de 
      Gran Canaria, Spain.
FAU - Gopar-Gopar, Silvia
AU  - Gopar-Gopar S
AD  - Cardiology Service, Insular-Materno Infantil University Hospital, Las Palmas de 
      Gran Canaria, Spain.
FAU - Rodriguez-Gonzalez, Fayna
AU  - Rodriguez-Gonzalez F
AD  - Dr. Negrin University Hospital of Gran Canaria, Las Palmas de Gran Canaira, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20170329
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Echocardiography/*methods
MH  - Female
MH  - Heart Ventricles/diagnostic imaging/physiopathology
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Transposition of Great Vessels/*blood/*complications/diagnostic imaging
MH  - Ventricular Dysfunction, Right/*complications/*diagnostic imaging
OTO - NOTNLM
OT  - congenital heart defects
OT  - dextro-transposition of the great arteries
OT  - myocardial performance index
OT  - right ventricular function
OT  - tissue doppler imaging
OT  - tricuspid annular plane systolic excursion
OT  - tricuspid regurgitation
EDAT- 2017/04/04 06:00
MHDA- 2018/04/19 06:00
CRDT- 2017/04/04 06:00
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2018/04/19 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 10.1111/echo.13526 [doi]
PST - ppublish
SO  - Echocardiography. 2017 Jun;34(6):876-880. doi: 10.1111/echo.13526. Epub 2017 Mar 
      29.