PMID- 28370664
OWN - NLM
STAT- MEDLINE
DCOM- 20180305
LR  - 20181003
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 45
IP  - 10
DP  - 2017 May
TI  - An acute bout of exercise modulates both intracortical and interhemispheric 
      excitability.
PG  - 1343-1355
LID - 10.1111/ejn.13569 [doi]
AB  - Primary motor cortex (M1) excitability is modulated following a single session of 
      cycling exercise. Specifically, short-interval intracortical inhibition and 
      intracortical facilitation are altered following a session of cycling, suggesting 
      that exercise affects the excitability of varied cortical circuits. Yet we do not 
      know whether a session of exercise also impacts the excitability of 
      interhemispheric circuits between, and other intracortical circuits within, M1. 
      Here we present two experiments designed to address this gap in knowledge. In 
      experiment 1, single and paired pulse transcranial magnetic stimulation (TMS) 
      were used to measure intracortical circuits including, short-interval 
      intracortical facilitation (SICF) tested at 1.1, 1.5, 2.7, 3.1 and 4.5 ms 
      interstimulus intervals (ISIs), contralateral silent period (CSP) and 
      interhemispheric interactions by measuring transcallosal inhibition (TCI) 
      recorded from the abductor pollicus brevis muscles. All circuits were assessed 
      bilaterally pre and two time points post (immediately, 30 min) moderate intensity 
      lower limb cycling. SICF was enhanced in the left hemisphere after exercise at 
      the 1.5 ms ISI. Also, CSP was shortened and TCI decreased bilaterally after 
      exercise. In Experiment 2, corticospinal and spinal excitability were tested 
      before and after exercise to investigate the locus of the effects found in 
      Experiment 1. Exercise did not impact motor-evoked potential recruitment curves, 
      Hoffman reflex or V-wave amplitudes. These results suggest that a session of 
      exercise decreases intracortical and interhemispheric inhibition and increases 
      facilitation in multiple circuits within M1, without concurrently altering spinal 
      excitability. These findings have implications for developing exercise strategies 
      designed to potentiate M1 plasticity and skill learning in healthy and clinical 
      populations.
CI  - (c) 2017 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
FAU - Neva, J L
AU  - Neva JL
AUID- ORCID: 0000-0002-8211-9923
AD  - Department of Physical Therapy, Faculty of Medicine, University of British 
      Columbia, 212-2177 Westbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
FAU - Brown, K E
AU  - Brown KE
AD  - Department of Physical Therapy, Faculty of Medicine, University of British 
      Columbia, 212-2177 Westbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
FAU - Mang, C S
AU  - Mang CS
AD  - Department of Physical Therapy, Faculty of Medicine, University of British 
      Columbia, 212-2177 Westbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
FAU - Francisco, B A
AU  - Francisco BA
AD  - Department of Physical Therapy, Faculty of Medicine, University of British 
      Columbia, 212-2177 Westbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
FAU - Boyd, L A
AU  - Boyd LA
AD  - Department of Physical Therapy, Faculty of Medicine, University of British 
      Columbia, 212-2177 Westbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170424
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
SB  - IM
MH  - Adult
MH  - Corpus Callosum/physiology
MH  - *Exercise
MH  - *Functional Laterality
MH  - Humans
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition
MH  - Pyramidal Tracts/physiology
OTO - NOTNLM
OT  - exercise
OT  - intracortical excitability
OT  - primary motor cortex
OT  - transcallosal inhibition
OT  - transcranial magnetic stimulation
EDAT- 2017/04/04 06:00
MHDA- 2018/03/06 06:00
CRDT- 2017/04/04 06:00
PHST- 2016/08/18 00:00 [received]
PHST- 2017/03/23 00:00 [revised]
PHST- 2017/03/24 00:00 [accepted]
PHST- 2017/04/04 06:00 [pubmed]
PHST- 2018/03/06 06:00 [medline]
PHST- 2017/04/04 06:00 [entrez]
AID - 10.1111/ejn.13569 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2017 May;45(10):1343-1355. doi: 10.1111/ejn.13569. Epub 2017 Apr 
      24.